ArticleAmerican journal of ophthalmology2020
Retinal Vasculometry Associations With Glaucoma: Findings From the European Prospective Investigation of Cancer-Norfolk Eye Study.
Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Retinomics as a Tool for Glaucoma Prediction.Ophthalmology science · 2026Article
- Retinal vascular alteration following surgical intraocular pressure reduction in primary angle closure disease.BMJ open ophthalmology · 2026Article
- Gasotransmitters in Glaucoma: A New Paradigm.Bulletin of pharmaceutical research · 2026Article
- Longitudinal associations of retinal vessel morphology with intraocular pressure and blood pressure at follow-up visit-Findings from a Danish eye and vision cohort, Project FOREVER.Acta ophthalmologica · 2025Article
- GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma.Nature communications · 2024Article
- GWAS on retinal vasculometry phenotypes.PLoS genetics · 2023Article
- Automated analysis of vessel morphometry in retinal images from a Danish high street optician setting.PloS one · 2023Article
- Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population.Translational vision science & technology · 2022Article
- Computerized Analysis of the Eye Vasculature in a Mass Dataset of Digital Fundus Images: The Example of Age, Sex, and Primary Open-Angle Glaucoma.Ophthalmology scienceArticle
- Retinal Vessel Traits and Age-Related Eye Disease in the Canadian Longitudinal Study on Aging.Clinical & experimental ophthalmologyArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
purposeTo examine retinal vasculometry associations with different glaucomas in older British people.
designCross-sectional study.
methodsA total of 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glaucoma suspect [GS], high-tension open-angle glaucoma [HTG], and normal-tension glaucoma [NTG]). Automated measures of arteriolar and venular tortuosity, area, and width from retinal images were obtained. MainOutcomeMeasures: Associations between glaucoma and retinal vasculometry outcomes were analyzed using multilevel linear regression, adjusted for age, sex, height, axial length, intraocular and systemic blood pressure, and within-person clustering, to provide absolute differences in width and area, and percentage differences in vessel tortuosity. Presence or absence of within-person-between-eye differences in retinal vasculometry by diagnoses were examined.
resultsA total of 565,593 vessel segments from 5,947 participants (mean age 67.6 years, SD 7.6 years, 57% women) were included; numbers with HTG, NTG, and GS in at least 1 eye were 87, 82, and 439, respectively. Thinner arterioles (-3.2 μm; 95% confidence interval [CI] -4.4 μm, -1.9 μm) and venules (-2.7 μm; 95% CI -4.9 μm, -0.5 μm) were associated with HTG. Reduced venular area was associated with HTG (-0.2 mm
conclusionsRetinal vessel width associations with glaucoma and novel associations with vessel area and tortuosity, together with no evidence of within-person-between-eye differences in retinal vasculometry, suggest a vascular cause of glaucoma.
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