Evidence map›Paper›PMID 32717264›Full record

ArticleChest2020

Clinical Presentation and Outcomes of Acute Pericarditis in a Large Urban Hospital in the United States of America.

Alessandra Vecchié, Juan G Chiabrando, Megan S Dell, Aldo Bonaventura, Adolfo G Mauro, George Wohlford, Benjamin W Van Tassell, Daniel H Berrocal, Fabrizio Montecucco, Anna Beutler and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Alessandra VecchiéPauley Heart Center, Virginia Commonwealth University, Richmond, VA; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Juan G ChiabrandoPauley Heart Center, Virginia Commonwealth University, Richmond, VA; Interventional Cardiology Department, Hospital Italiano of Buenos Aires, Buenos Aires, Argentina.
Megan S DellDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA.
Aldo BonaventuraPauley Heart Center, Virginia Commonwealth University, Richmond, VA; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Adolfo G MauroPauley Heart Center, Virginia Commonwealth University, Richmond, VA.
George WohlfordDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, VA.
Benjamin W Van TassellDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, VA.
Daniel H BerrocalInterventional Cardiology Department, Hospital Italiano of Buenos Aires, Buenos Aires, Argentina.
Fabrizio MontecuccoIRCCS Ospedale Policlinico San Martino Genova-Italian Cardiovascular Network, Genoa, Italy; First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.
Anna BeutlerKiniksa Pharmaceuticals Ltd., Lexington, MA.
John F PaoliniKiniksa Pharmaceuticals Ltd., Lexington, MA.
Tamas S GalDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA.
Antonio AbbatePauley Heart Center, Virginia Commonwealth University, Richmond, VA. Electronic address: antonio.abbate@vcuhealth.org.
Virginia Commonwealth University · USSynta Pharmaceuticals (United States) · USUniversity of Genoa · ITHospital Italiano de Buenos Aires · AR

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
NCATS NIH HHS UL1 TR002649
6 · The paper itself

Abstract

backgroundAcute pericarditis is the most common presentation of pericardial diseases. Although generally benign, complications such as constrictive pericarditis, cardiac tamponade, and recurrence can occur. RESEARCH QUESTION: What are the clinical factors associated with adverse outcomes in acute pericarditis? STUDY DESIGN AND

methodsWe used an informatics-based search engine to search for International Classification of Diseases codes related to pericardial disease between January 1, 2009 and November 14, 2018 and then extracted clinical information, including only patients meeting the European Society of Cardiology criteria for acute pericarditis. We then evaluated the predictive value of clinical characteristics for adverse outcomes (cardiac tamponade, constrictive pericarditis, failure of therapy, recurrences, or death).

resultsWe identified 240 patients with a first episode of pericarditis (51 [34-62] years, 56% males and 50% white). Pericarditis was determined to be idiopathic in 126 (53%) cases and related to cardiac injury in 79 (33%). During a median follow-up time of 179 (20-450) days, 82 (34%) patients experienced at least one adverse outcome. Subacute presentation was an independent predictor of adverse outcomes. Patients with postcardiac injury pericarditis had a lower incidence in the composite of failure of treatment and recurrence (13% vs 26%; P = .022) compared with patients with idiopathic pericarditis. Troponin I measurements were obtained in 167 patients (70%). Elevated troponin I levels were associated with lower incidence of recurrences (4% vs 17%; P = .024) and of the composite outcome (13% vs 36%; P = .004).

interpretationAcute pericarditis is associated with at least one adverse outcome in 34% of patients. Subacute presentation and idiopathic etiology are associated with higher incidence of adverse outcomes, whereas elevated troponin I levels identify a group with reduced risk of recurrences.

Indexed as

Cardiac TamponadeHeart InjuriesPericardial EffusionPericarditisFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPatient AcuityPrognosisRecurrenceRisk AssessmentTroponin IUnited StatesTroponin Iacute pericarditisrecurrencesubacute presentationtherapy failuretroponin I

Identifiers

PMID32717264
PMCPMC7768931
OpenAlexW3044947338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.