Evidence map›Paper›PMID 32717179›Full record

ArticleeLife2020

Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data.

Simon P Hood, Georgina Cosma, Gemma A Foulds, Catherine Johnson, Stephen Reeder, Stéphanie E McArdle, Masood A Khan, A Graham Pockley

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Simon P Hood *John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Georgina Cosma *Department of Computer Science, Loughborough University, Loughborough, United Kingdom.ORCID https://orcid.org/0000-0002-4663-6907
Gemma A FouldsJohn van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Catherine JohnsonJohn van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Stephen ReederJohn van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Stéphanie E McArdleJohn van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Masood A KhanDepartment of Urology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
A Graham Pockley *John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-9593-6431
Nottingham Trent University · GBLoughborough University · GBUniversity Hospitals of Leicester NHS Trust · GBUniversity of Manchester · GB

Funding

ERDF Healthcare and Bioscience iNet Research GrantLeverhulme Trust Research Project Grant RPG-2016-252Nottingham Trent University PhD StudentshipPROSTaid Prostate Cancer Charity Funding SupportThe John and Lucille van Geest Foundation Core / Programme Grant
6 · The paper itself

Abstract

We demonstrate that prostate cancer can be identified by flow cytometric profiling of blood immune cell subsets. Herein, we profiled natural killer (NK) cell subsets in the blood of 72 asymptomatic men with Prostate-Specific Antigen (PSA) levels < 20 ng ml

Indexed as

AgedAged, 80 and overAsymptomatic DiseasesBlood CirculationDiagnostic Techniques, UrologicalFlow CytometryHumansKiller Cells, NaturalMachine LearningMaleMiddle AgedPractice Guidelines as TopicProstate-Specific AntigenProstatic NeoplasmsRisk AssessmentProstate-Specific Antigencancer biologycomputational biologydiagnosishumanimmune phenotypingmachine learningnatural killer (NK) cellsprostate cancerprostate specific antigen (psa)systems biology

Identifiers

PMID32717179
PMCPMC7386909
OpenAlexW3045026474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.