Evidence map›Paper›PMID 32717025›Full record

ArticleOperative neurosurgery (Hagerstown, Md.)2020

The Effects of Postoperative Neurological Deficits on Survival in Patients With Single Brain Metastasis.

Ravi Medikonda, Christopher M Jackson, James Feghali, Michael Lim

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Article in Operative neurosurgery (Hagerstown, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ravi MedikondaDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Christopher M JacksonDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
James FeghaliDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael LimDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognosis for brain metastasis is poor, and surgical resection is part of the standard of care for these patients as it has been shown to improve median overall survival. Development of neurological deficits after surgical resection has been associated with worsened outcomes in patients with glioblastoma. The effect of postoperative neurological deficits on survival in patients with single brain metastasis has not been studied to date.

objectiveTo evaluate the association between postoperative neurological deficits and median overall survival.

methodsA single-institution retrospective cohort study was performed on all patients with single brain metastasis undergoing surgical resection by a single neurosurgeon.

resultsA total of 121 patients met the inclusion criteria for this study. Among them 61% of patients presented with a preoperative deficit, and 26% of patients had a new postoperative deficit. However, most postoperative deficits resolved and only 3.3% of patients developed a new permanent postoperative deficit. Median overall survival in patients with a new postoperative deficit was 2.4 mo, whereas mOS in patients without a postoperative deficit was 12.6 mo (P < .0001).

conclusionThis study suggests that a new neurological deficit is associated with worsened outcomes after surgical resection of a single brain metastasis. This finding has potential implications for patient selection and counseling as the patients most likely to benefit from surgical resection are the patients who are most likely to have resolution of a preoperative deficit.

Indexed as

Brain NeoplasmsGlioblastomaHumansPostoperative ComplicationsPostoperative PeriodRetrospective StudiesBrain metastasisNeurological deficitsPostoperative deficitSingle brain metastasis

Identifiers

PMID32717025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.