ArticleDevelopmental cognitive neuroscience2020
Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth.
Article in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- In relation to anxiety severity, puberty moderates functional connectivity between the amygdala and anterior cingulate cortex for negative relative to neutral stimuli during an emotional categorization task.Developmental cognitive neuroscience · 2026Article
- Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.European child & adolescent psychiatry · 2026Article
- Sex Differences in the Interaction of Epigenetic Risk and Trajectories of Default Mode Limbic Network Integration Predicting Childhood Anxiety.Research square · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in brain network functional connectivity and their association with gene expression profiles in major depressive disorder: a REST-meta-MDD project-based study.Brain imaging and behavior · 2025Article
- Investigating sex differences in developmental origins of adolescent depression.Frontiers in child and adolescent psychiatry · 2025Article
- Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study®.Psychiatry research. Neuroimaging · 2024Article
- Sex-specific resting state brain network dynamics in patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
- Article
- Gray space and default mode network-amygdala connectivity.Frontiers in human neuroscience · 2023Article
- Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children.Brain communications · 2022Article
- Intimate partner violence: psycho-physio-pathological sequelae for defining a holistic enriched treatment.Frontiers in behavioral neuroscience · 2022Article
- Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI.Frontiers in rehabilitation sciences · 2022Article
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
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Authors and funding
6 authors.
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Abstract
Amygdala resting-state functional connectivity (rsFC) is altered in adolescents with internalizing disorders, though the relationship between rsFC and subclinical symptomatology in neurotypical youth remains unclear. Here we examined whether amygdala rsFC varied across a continuum of internalizing symptoms in 110 typically-developing (TD) youths 8 to 17 years old using functional magnetic resonance imaging (fMRI). We assessed overall internalizing symptoms, as well as anxious-depressed, withdrawn-depressed, and somatic complaints. Given known sex differences in the prevalence of internalizing disorders, we compared connectivity between males and females. As compared to males, females with greater internalizing, anxious-depressed, and somatic symptoms displayed greater connectivity with the cingulate gyrus, insula, and somatosensory cortices. In contrast, males with greater anxious-depressed symptoms demonstrated weaker connectivity with the subcallosal prefrontal cortex. Sex differences in rsFC in relation to symptom severity were evident for the whole amygdala and for two of its subnuclei (centromedial and superficial amygdala). Overall, results suggest that, for females, higher internalizing symptoms are associated with greater rsFC between the amygdala and regions implicated in emotional and somatosensory processing, salience detection, and action selection. Future longitudinal investigations are needed to determine whether this hyperconnectivity may confer resilience to, or pose risk for, the development of internalizing disorders.
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