Evidence map›Paper›PMID 32716714›Full record

ArticlePsychological science2020

The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology.

Daniel E Gustavson, Naomi P Friedman, Pierre Fontanillas, Sarah L Elson, 23andMe Research Team, Abraham A Palmer, Sandra Sanchez-Roige

Abstract read
In one paragraph

Article in Psychological science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  6. Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity.Clinical psychological science : a journal of the Association for Psychological Science · 2025
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  19. Contexts of urgency may go beyond emotion.Frontiers in psychiatry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel E GustavsonDepartment of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-1470-4928
Naomi P FriedmanDepartment of Psychology and Neuroscience, University of Colorado Boulder.ORCID 0000-0002-4901-808X
Pierre Fontanillas23andMe, Sunnyvale, California.
Sarah L Elson23andMe, Sunnyvale, California.
23andMe Research Team23andMe, Sunnyvale, California.
Abraham A PalmerDepartment of Psychiatry, University of California, San Diego.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California, San Diego.

Funding

Neural Substrates of Executive Function: An fMRI Twin StudyR01MH063207 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FRIEDMAN, NAOMI P. · 2001 to 2018
$6.5M
Neurobiological Markers of Rhythm: Risk and Resilience for Language AcquisitionR01DC016977 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORDON, REYNA LEIGH · 2019 to 2023
$3.5M
Brain and Genetic Predictors of Individual Differences in Pain and Placebo AnalgesiaR01DA046064 · NIDA · UNIVERSITY OF COLORADO · PI FRIEDMAN, NAOMI P., WAGER, TOR D. · 2018 to 2022
$3.2M
A Twin Study of Adolescent Alcohol and Drug Use Development: Leveraging Intensive Longitudinal AssessmentsU01DA046413 · NIDA · UNIVERSITY OF MINNESOTA · PI FRIEDMAN, NAOMI P., VRIEZE, SCOTT IAN · 2018 to 2022
$2.7M
Biomarkers of Rhythmic Communication: Integrating Foundational and Translational ApproachesDP2HD098859 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORDON, REYNA LEIGH · 2018 to 2018
$2.4M
Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Executive Functions and Self-Regulation: A Twin StudyR56MH063207 · NIMH · UNIVERSITY OF COLORADO · PI HEWITT, JOHN K. · 2007 to 2007
$490k
NICHD NIH HHS DP2 HD098859NIDA NIH HHS R01 DA042742NIDA NIH HHS R01 DA046064NIDA NIH HHS U01 DA046413NIDCD NIH HHS R01 DC016977NIMH NIH HHS R01 MH063207NIMH NIH HHS R56 MH063207
6 · The paper itself

Abstract

Factor analyses suggest that impulsivity traits that capture tendencies to act prematurely or take risks tap partially distinct constructs. We applied genomic structure equation modeling to evaluate the genetic factor structure of two well-established impulsivity questionnaires, using published statistics from genome-wide association studies of up to 22,861 participants. We also tested the hypotheses that delay discounting would be genetically separable from other impulsivity factors and that emotionally triggered facets of impulsivity (urgency) would be those most strongly genetically correlated with an internalizing latent factor. A five-factor model best fitted the impulsivity data. Delay discounting was genetically distinct from these five factors. As expected, the two urgency subscales were most strongly related to an internalizing-psychopathology latent factor. These findings provide empirical genetic evidence that impulsivity can be broken down into distinct categories of differential relevance for internalizing psychopathology. They also demonstrate how measured genetic markers can be used to inform theories of psychology and personality.

Indexed as

Defense MechanismsDelay DiscountingFactor Analysis, StatisticalFemaleGenetic StructuresGenome-Wide Association StudyHumansImpulsive BehaviorMalePersonalityPsychopathologyBarratt Impulsiveness Scalegenomic structural equation modelingheritabilityopen dataopen materialsself-controlUPPS-P Impulsive Behavior Scale

Identifiers

PMID32716714
PMCPMC7427138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.