Evidence map›Paper›PMID 32716350›Full record

Observational studyCancer biomarkers : section A of Disease markers2020

MicroRNA-629 promotes the tumorigenesis of non-small-cell lung cancer by targeting FOXO1 and activating PI3K/AKT pathway.

Lin Zhu, Yinan Chen, Jing Liu, Kai Nie, Yongxin Xiao, Hong Yu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer biomarkers : section A of Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lin ZhuDepartment of Radiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Yinan ChenDepartment of Radiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Jing LiuDepartment of Radiology, Dongfang Hospital Affiliated to Shanghai Tongji University, Shanghai, China.
Kai NieDepartment of Radiology, Shanghai Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai, China.
Yongxin XiaoDepartment of Radiology, Shanghai Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai, China.
Hong YuDepartment of Radiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Shanghai Chest Hospital · CNSecond Military Medical University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNA-629 (miR-629) has been found to play an important role in the pathogenesis of human cancers. However, the function of miR-629 is still unknown in non-small-cell lung cancer (NSCLC). The purpose of this study is to preliminarily elucidate the regulatory mechanism of miR-629 in NSCLC. MATERIALS AND

methodsThe mRNA and protein expression was measured by real-time quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The function of miR-629 was investigated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) and Transwell assays. The relationship between miR-629 and FOXO1 was confirmed by dual luciferase assay.

resultsMiR-629 was upregulated in NSCLC tissues and cells. High expression of miR-629 predicted poor prognosis in patients with NSCLC. Moreover, miR-629 promoted cell proliferation, migration and invasion in NSCLC cells. In addition, FOXO1 was confirmed as a direct target of miR-629 in NSCLC. Furthermore, knockdown of FOXO1 also promoted proliferation, migration and invasion of NSCLC cells. More importantly, overexpression of FOXO1 weakened the carcinogenesis of miR-629 in NSCLC. Besides that, miR-629 promoted EMT and activated the PI3K/AKT pathway in NSCLC.

conclusionsMiR-629 promotes the progression of NSCLC by targeting FOXO1 and regulating EMT/PI3K/AKT pathway.

Indexed as

A549 CellsCarcinogenesisCarcinoma, Non-Small-Cell LungCell MovementCell ProliferationComputational BiologyDown-RegulationEpithelial-Mesenchymal TransitionFemaleForkhead Box Protein O1Gene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLungLung NeoplasmsMaleAKT1 protein, humanForkhead Box Protein O1FOXO1 protein, humanMicroRNAsMIRN629 microRNA, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktFOXO1miR-629non-small-cell lung cancerPI3K/AKT pathway

Identifiers

PMID32716350
PMCPMC12662520
OpenAlexW3045479044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.