ArticleCognitive neuroscience
Sex-related differences in brain dynamism at rest as neural correlates of positive and negative valence system constructs.
Article in Cognitive neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Multivariate multiscale entropy (mMSE) as a tool for understanding the resting-state EEG signal dynamics: the spatial distribution and sex/gender-related differences.Behavioral and brain functions : BBF · 2023Article
- Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data.Life (Basel, Switzerland) · 2023Review
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Clinical anxiety and depression are the most prevalent mental illnesses, likely representing maladaptive expressions of negative valence systems concerned with conditioned responses to fear, threat, loss, and frustrative nonreward. These conditions exhibit similar, striking sex/gender-related differences in onset, incidence, and severity for which the neural correlates are not yet established. In alarge sample of neurotypical young adults, we demonstrate that intrinsic brain dynamism metrics derived from sex-sensitive models of whole-brain network function are significantly associated with valence system traits. Surprisingly, we found that greater brain dynamism is strongly positively correlated to anxiety and depression traits in males, but almost wholly decoupled from traits for important cognitive control and reappraisal strategies associated with positive valence. Conversely, intrinsic brain dynamism is strongly positively coupled to drive, novelty-seeking and self-control in females with only rare or non-significant directional negative correlation with anxiety and depression traits. Our results suggest that the dynamic neural correlates of traits for valence, anxiety and depression are significantly different in males/men and females/women. These findings may relate to the known sex/gender-related differences in cognitive reappraisal of emotional experiences and clinical presentations of anxiety and depression, with potential relevance to gold standard therapies based on enhancing cognitive control strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.