Evidence map›Paper›PMID 32715763›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury.

Yongzhen Zhao, Heng Zeng, Bo Liu, Xiaochen He, Jian-Xiong Chen

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Role of local angiotensin II signaling in bladder function.American journal of physiology. Renal physiology · 2024
    Review
  3. PHD1-3 oxygen sensors in vivo-lessons learned from gene deletions.Pflugers Archiv : European journal of physiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yongzhen ZhaoDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Heng ZengDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Bo LiuDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Xiaochen HeDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-8266-5895
Jian-Xiong ChenDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · US

Funding

Regulation of vascular maturation/regression in diabetesR01HL102042 · NHLBI · VANDERBILT UNIVERSITY · PI CHEN, JIAN-XIONG · 2010 to 2020
$3.0M
NHLBI NIH HHS R01 HL102042NHLBI NIH HHS R01HL102042
6 · The paper itself

Abstract

Angiotensin II (ANG II) is the key contributor to renal fibrosis and injury. The present study investigated the role of endothelium prolyl hydroxylase 2 (PHD2) in ANG II-mediated renal fibrosis and injury. In vitro, endothelial cells (ECs) were isolated from PHD2

Indexed as

Angiotensin IIAnimalsEndothelial CellsEndotheliumFibrosisHypoxia-Inducible Factor-Proline DioxygenasesKidneyKidney DiseasesMiceMice, KnockoutProcollagen-Proline DioxygenaseRNA, Small InterferingAngiotensin IIEgln1 protein, mouseHypoxia-Inducible Factor-Proline DioxygenasesProcollagen-Proline DioxygenaseRNA, Small Interferingangiotensin IIhypoxia-inducible factorprolyl hydroxylase 2reactive oxygen speciesrenal fibrosis

Identifiers

PMID32715763
PMCPMC7473903
OpenAlexW3045938576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.