Evidence map›Paper›PMID 32715735›Full record

ReviewCartilage2021

Autologous Minced Cartilage Implantation for Treatment of Chondral and Osteochondral Lesions in the Knee Joint: An Overview.

Gian M Salzmann, Robert Ossendorff, Ron Gilat, Brian J Cole

Registry-linked trialAbstract readReview
In one paragraph

Review in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07641868 (Management of Focal Cartilage Lesions of the Knee), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07641868 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure

TypeinterventionalSponsorLouis Pasteur Santé LorraineRan2026 to 2030Enrolled80ConditionsFocal Cartilage Lesions of the KneeArmsManagement of focal cartilage lesions of the knee: micro-fracture, Minced Cartilage Implantation (MCI)
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMICEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gian M SalzmannGelenkzentrum Rhein-Main, Wiesbaden, Germany.
Robert OssendorffClinic for Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-6636-8065
Ron GilatMidwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.
Brian J ColeMidwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage defects in the knee are being diagnosed with increased frequency and are treated with a variety of techniques. The aim of any cartilage repair procedure is to generate the highest tissue quality, which might correlate with improved clinical outcomes, return-to-sport, and long-term durability. Minced cartilage implantation (MCI) is a relatively simple and cost-effective technique to transplant autologous cartilage fragments in a single-step procedure. Minced cartilage has a strong biologic potential since autologous, activated non-dedifferentiated chondrocytes are utilized. It can be used both for small and large cartilage lesions, as well as for osteochondral lesions. As it is purely an autologous and homologous approach, it lacks a significant regulatory oversight process and can be clinically adopted without such limitations. The aim of this narrative review is to provide an overview of the current evidence supporting autologous minced cartilage implantation.

Indexed as

Cartilage, ArticularCartilage DiseasesChondrocytesHumansKnee JointTransplantation, Autologousarticular cartilagecartilage defectcartilage regenerationcartilage repairminced cartilage implantation

Identifiers

PMID32715735
PMCPMC8808955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.