ArticleESC heart failure2020
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016.
Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Health Effects of Cyclones: A Systematic Review and Meta-Analysis of Epidemiological Studies.Environmental health perspectives · 2023Pooled it
- The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Associations Between Acute Heat Exposure and Hospitalization for Takotsubo Syndrome in the State of California, 2006 to 2019.Journal of the American Heart Association · 2026Article
- Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study.Frontiers in cardiovascular medicine · 2026Article
- Article
- Development of a small animal model replicating core characteristics of takotsubo syndrome in humans.European heart journal open · 2024Article
- Body Mass Index and Outcomes in Patients with Takotsubo Syndrome: A Nationwide Retrospective Cohort Study.Cardiology · 2024Article
- Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study.European heart journal. Acute cardiovascular care · 2023Article
- Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis.Medical sciences (Basel, Switzerland) · 2023Article
- "Obesity paradox" and takotsubo syndrome.International journal of cardiology. Cardiovascular risk and prevention · 2022Review
- Efficacy of Early Cardiac Rehabilitation After Cardiac Surgery - Verification Using Japanese Diagnosis Procedure Combination Data.Circulation reports · 2022Article
- Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan.Scientific reports · 2022Article
- Impact of Hurricanes and Associated Extreme Weather Events on Cardiovascular Health: A Scoping Review.Environmental health perspectives · 2022Article
- Article
- Hyperthermia as a trigger for Takotsubo syndrome in a rat model.Frontiers in cardiovascular medicine · 2022Article
- Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016.ESC heart failure · 2020Article
- Validity of diagnoses, procedures, and birth records in a Japanese administrative claims database for pediatric patients.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to investigate the influence of climatic factors on the onset of Takotsubo syndrome (TTS). METHODS AND
resultsWe performed a retrospective nationwide study among patients registered in the Japanese Registry of All Cardiac and Vascular Diseases and Diagnosis Procedure Combination (JROAD-DPC) discharge database, between 2012 and 2016. Before the analysis, a multicentre validation study was conducted for assessing the accuracy of the JROAD-DPC classification for TTS. First, we investigated the seasonal variation of incidences of TTS. Second, we analysed the associations between the incidence of TTS and climatic factors using the hierarchical Poisson regression modelling, and we also investigated the associations between typhoon landfalls and hospitalization for TTS, using the fixed-effects conditional Poisson regression model. The sensitivity and specificity for diagnosis were 83% and 100%, respectively. Then we analysed 5643 patients with TTS. The mean patient age was 74 (standard deviation ± 11) years; 79% were female. TTS was diagnosed significantly more frequently in the summer and early autumn. The incidence of TTS was related to higher temperatures; adjusted incidence rate ratios were 1.46 [95% confidence interval (CI): 1.33-1.60, P < 0.01] and 1.47 (95% CI: 1.34-1.62, P < 0.01) for temperatures of 20-25°C and >25°C, respectively. The incidence rate ratio for the first 2 days after a typhoon landfall was 1.85 (95% CI: 1.07-3.19; P = 0.03).
conclusionsThis study demonstrates distinct patterns of seasonal variation in the incidence of TTS, as well as a significant association between its onset and climatic factors, including typhoon landfalls.
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