Evidence map›Paper›PMID 32715571›Full record

ArticleJournal of occupational health2020

Exposure to 1-bromopropane vapors during pregnancy enhances the development of hippocampal neuronal excitability in rat pups during lactation.

Yukiko Fueta, Susumu Ueno, Toru Ishidao, Yasuhiro Yoshida, Yasunari Kanda, Hajime Hori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yukiko FuetaDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID https://orcid.org/0000-0002-2383-6500
Susumu UenoDepartment of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Toru IshidaoDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yasuhiro YoshidaDepartment of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID https://orcid.org/0000-0003-1658-3119
Yasunari KandaDivision of Pharmacology, National Institute of Health Sciences, Kawasaki, Japan.
Hajime HoriDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JPNational Institute of Health Sciences · JP

Funding

Japan Society for the Promotion of Science (JSPS) 18510064Japan Society for the Promotion of Science (JSPS) 20591237Ministry of Health, Labour and Welfare, Japan 19KD1003University of Occupational and Environmental Health (UOEH) Research Grant for Promotion of Occupational Health
6 · The paper itself

Abstract

objectivesAlthough 1-Bromopropane (1-BP) exposure has been reported to cause neurotoxicity in adult humans and animals, its effects on the development of the central nervous system remain unclear. Recently, we reported delayed developmental neurotoxicity (DNT) upon 1-BP exposure in rats. Here we aimed to study the effect of prenatal 1-BP exposure on the hippocampal excitability in the juvenile offspring.

methodsPregnant Wistar rats were exposed to vaporized 1-BP for 20 days (6 h/d) with concentrations of 0 (control), 400, or 700 ppm. Hippocampal slices were prepared from male offspring during postnatal days (PNDs) 13, 14, and 15. Field excitatory postsynaptic potential (fEPSP) and population spike (PS) were recorded simultaneously from the CA1 region.

resultsIn the exposed groups, the stimulation/response relationships of fEPSP slope and PS amplitude were enhanced more than in the control group at PND 14. Analysis of fEPSP-spike coupling demonstrated increased values of Top and Eslope50 in the exposed groups. Real-time PCR analysis showed a significant increase in the mRNA levels of the adult type Na

conclusionsOur results provide evidence that prenatal exposure to 1-BP accelerates developmental enhancement of hippocampal excitability in the pups before eye-opening. The current study suggests that our evaluation method of DNT is applicable to the industrial chemical 1-BP.

Indexed as

Inhalation ExposureLactationAnimalsCA1 Region, HippocampalCortical ExcitabilityFemaleHydrocarbons, BrominatedPregnancyPrenatal Exposure Delayed EffectsRatsRats, Wistar1-bromopropaneHydrocarbons, Brominated1-bromopropaneCA1 field of hippocampuselectrophysiologypostnatal developmenttoxicology

Identifiers

PMID32715571
PMCPMC7383040
OpenAlexW3045917047

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.