Evidence map›Paper›PMID 32715408›Full record

ArticleMolecular and cellular biochemistry2020

Targeting glutathione with the triterpenoid CDDO-Im protects against benzo-a-pyrene-1,6-quinone-induced cytotoxicity in endothelial cells.

Halley Shukla, Ho Young Lee, Ashkon Koucheki, Humaira A Bibi, Gabriella Gaje, Xiaolun Sun, Hong Zhu, Y Robert Li, Zhenquan Jia

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Halley ShuklaDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA.
Ho Young LeeDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA.
Ashkon KouchekiDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA.
Humaira A BibiDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA.
Gabriella GajeDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA.
Xiaolun SunCenter of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR, 72701, USA.
Hong ZhuCampbell University School of Osteopathic Medicine, Buies Creek, NC, USA.
Y Robert LiCampbell University School of Osteopathic Medicine, Buies Creek, NC, USA.
Zhenquan JiaDepartment of Biology, The University of North Carolina At Greensboro, 312 Eberhart Building, 321 McIver Street, Greensboro, NC, 27402-6170, USA. z_jia@uncg.edu.ORCID http://orcid.org/0000-0002-5187-1549
University of North Carolina at Greensboro · USCampbell University · USUniversity of Arkansas at Fayetteville · US

Funding

University of North Carolina at Greensboro Regular Faculty Research Award
6 · The paper itself

Abstract

Epidemiological studies have exhibited a strong correlation between exposure to air pollution and deaths due to vascular diseases such as atherosclerosis. Benzo-a-pyrene-1,6-quinone (BP-1,6-Q) is one of the components of air pollution

Indexed as

ApoptosisCytoprotectionBenzopyrenesCells, CulturedEndothelium, VascularGlutathioneHumansImidazolesLipid PeroxidationNecrosisOleanolic AcidProtective AgentsReactive Oxygen SpeciesThiobarbituric Acid Reactive Substances1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazolebenzo(a)pyrene-1,6-quinoneBenzopyrenesGlutathioneImidazolesOleanolic AcidProtective AgentsReactive Oxygen SpeciesThiobarbituric Acid Reactive SubstancesBP-1,6-quinoneCell deathCytoprotectionEndothelial cellsGlutathione

Identifiers

PMID32715408
OpenAlexW3044484928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.