ArticleACS omega2020
Rapid Fabrication of Poly(methyl methacrylate) Devices for Lab-on-a-Chip Applications Using Acetic Acid and UV Treatment.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Exploiting Device Deformability for Fluid and Particle Manipulation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Thirty years of contact angles reveal universal design rules for wetting control.Scientific reports · 2026Article
- Tuning the structural, optical properties and antibacterial activity of poly(vinyl chloride)/poly(methyl methacrylate)/silver oxide nanocomposites for potential optoelectronic and medical applications.Scientific reports · 2025Article
- Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Review
- Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications.Biomimetics (Basel, Switzerland) · 2024Review
- Fabrication of a Three-Dimensional Microfluidic System from Poly(methyl methacrylate) (PMMA) Using an Intermiscibility Vacuum Bonding Technique.Micromachines · 2024Article
- Electrochemical biosensors on microfluidic chips as promising tools to study microbial biofilms: a review.Frontiers in cellular and infection microbiology · 2024Review
- Rapid-release reversible bonding of PMMA-based microfluidic devices with PBMA coating.Biomedical microdevices · 2023Article
- Effect of CuO Nanoparticles on the Optical, Structural, and Electrical Properties in the PMMA/PVDF Nanocomposite.Micromachines · 2023Article
- One-step fabrication of three-dimensional macropore copolymer-modified polycarbonate array by photo-crosslinking for protein immunoassay.RSC advances · 2023Article
- Skin models of cutaneous toxicity, transdermal transport and wound repair.Burns & trauma · 2023Review
- Role of Polymers in Microfluidic Devices.Polymers · 2022Review
- Surface Modification of Polymethylmethacrylate (PMMA) by Ultraviolet (UV) Irradiation and IPA Rinsing.Micromachines · 2022Article
- Bonding Strategies for Thermoplastics Applicable for Bioanalysis and Diagnostics.Micromachines · 2022Review
- A new RT-LAMP-on-a-Chip Instrument for SARS-CoV-2 diagnostics.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2022Article
- Microwave-Assisted Solvent Bonding for Polymethyl Methacrylate Microfluidic Device.Micromachines · 2022Article
- CFD Analysis and Life Cycle Assessment of Continuous Synthesis of Magnetite Nanoparticles Using 2D and 3D Micromixers.Micromachines · 2022Article
- Recent Advances in Thermoplastic Microfluidic Bonding.Micromachines · 2022Review
- Pressure-Free Assembling of Poly(methyl methacrylate) Microdevices via Microwave-Assisted Solvent Bonding and Its Biomedical Applications.Biosensors · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we introduce a new approach for rapid bonding of poly(methyl methacrylate) (PMMA)-based microdevices using an acetic acid solvent with the assistance of UV irradiation. For the anticipated mechanism, acetic acid and UV irradiation induced free radicals on the PMMA surfaces, and acrylate monomers subsequently formed cross-links to create a permanent bonding between the PMMA substrates. PMMA devices effectively bonded within 30 s at a low pressure using clamps, and a clogging-free microchannel was achieved with the optimized 50% acetic acid. For surface characterizations, contact angle measurements and bonding performance analyses were conducted using predetermined acetic acid concentrations to optimize bonding conditions. In addition, the highest bond strength of bonded PMMA was approximately 11.75 MPa, which has not been reported before in the bonding of PMMA. A leak test was performed over 180 h to assess the robustness of the proposed method. Moreover, to promote the applicability of this bonding method, we tested two kinds of microfluidic device applications, including a cell culture-based device and a metal microelectrode-integrated device. The results showed that the cell culture-based application was highly biocompatible with the PMMA microdevices fabricated using an acetic acid solvent. Moreover, the low pressure required during the bonding process supported the integration of metal microelectrodes with the PMMA microdevice without any damage to the metal films. This novel bonding method holds great potential in the ecofriendly and rapid fabrication of microfluidic devices using PMMA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.