Evidence map›Paper›PMID 32714864›Full record

ArticleFrontiers in oncology2020

Apoptin Regulates Apoptosis and Autophagy by Modulating Reactive Oxygen Species (ROS) Levels in Human Liver Cancer Cells.

Yiquan Li, Yilong Zhu, Jinbo Fang, Wenjie Li, Shanzhi Li, Xing Liu, Zirui Liu, Gaojie Song, Chao Shang, Jianan Cong and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yiquan LiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Yilong ZhuAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Jinbo FangAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Wenjie LiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Shanzhi LiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Xing LiuAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Zirui LiuInstitute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun, China.
Gaojie SongAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Chao ShangAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Jianan CongAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Bing BaiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Lili SunDepartment of Head and Neck Surgery, Tumor Hospital of Jilin Province, Changchun, China.
Ningyi JinAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Xiao LiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Academy of Military Medical Sciences · CNChangchun University of Chinese Medicine · CNJilin Province Tumor Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptin is a protein that specifically induces apoptosis in tumor cells. The anti-tumorigenic functions of Apoptin, including autophagy activation and its interaction with apoptosis, have not been precisely elucidated. Here we investigate the main pathways of apoptin-mediated killing of human liver cancer cells, as well as its putative role in autophagy and apoptosis. The anti-proliferative effect of apoptin in liver cancer cells was analyzed

Indexed as

apoptinapoptosisautophagyhuman liver cancerROS

Identifiers

PMID32714864
PMCPMC7344208
OpenAlexW3037140352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.