Evidence map›Paper›PMID 32714763›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Dynamic DNA Assemblies in Biomedical Applications.

Yaqin Hu, Ying Wang, Jianhua Yan, Nachuan Wen, Hongjie Xiong, Shundong Cai, Qunye He, Dongming Peng, Zhenbao Liu, Yanfei Liu

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. DNA Origami and Its Applications in Synthetic Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Scaling up of a Self-Confined Catalytic Hybridization Circuit for Robust microRNA Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  10. Review
  11. CRISPR/Cas9 systems: Delivery technologies and biomedical applications.Asian journal of pharmaceutical sciences · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Dynamic DNA Assemblies in Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaqin HuDepartment of Pharmaceutical Engineering College of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 P. R. China.
Ying WangDepartment of Pharmaceutical Engineering College of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 P. R. China.
Jianhua YanXiangya School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 P. R. China.
Nachuan WenDepartment of Pharmaceutical Engineering College of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 P. R. China.
Hongjie XiongXiangya School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 P. R. China.
Shundong CaiXiangya School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 P. R. China.
Qunye HeXiangya School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 P. R. China.
Dongming PengDepartment of Medicinal Chemistry School of Pharmacy Hunan University of Chinese Medicine Changsha Hunan 410013 P. R. China.
Zhenbao LiuXiangya School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 P. R. China.ORCID https://orcid.org/0000-0003-4740-7652
Yanfei LiuDepartment of Pharmaceutical Engineering College of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxyribonucleic acid (DNA) has been widely used to construct homogeneous structures with increasing complexity for biological and biomedical applications due to their powerful functionalities. Especially, dynamic DNA assemblies (DDAs) have demonstrated the ability to simulate molecular motions and fluctuations in bionic systems. DDAs, including DNA robots, DNA probes, DNA nanochannels, DNA templates, etc., can perform structural transformations or predictable behaviors in response to corresponding stimuli and show potential in the fields of single molecule sensing, drug delivery, molecular assembly, etc. A wave of exploration of the principles in designing and usage of DDAs has occurred, however, knowledge on these concepts is still limited. Although some previous reviews have been reported, systematic and detailed reviews are rare. To achieve a better understanding of the mechanisms in DDAs, herein, the recent progress on the fundamental principles regarding DDAs and their applications are summarized. The relative assembly principles and computer-aided software for their designing are introduced. The advantages and disadvantages of each software are discussed. The motional mechanisms of the DDAs are classified into exogenous and endogenous stimuli-triggered responses. The special dynamic behaviors of DDAs in biomedical applications are also summarized. Moreover, the current challenges and future directions of DDAs are proposed.

Indexed as

biomedical applicationsDNA nanotechnologydynamic DNA assemblies

Identifiers

PMID32714763
PMCPMC7375253

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.