Evidence map›Paper›PMID 32714757›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Enhancing the Efficacy of Metal-Free MRI Contrast Agents via Conjugating Nitroxides onto PEGylated Cross-Linked Poly(Carboxylate Ester).

Shiwei Guo, Xiaoming Wang, Yan Dai, Xinghang Dai, Zhiqian Li, Qiang Luo, Xiuli Zheng, Zhongwei Gu, Hu Zhang, Qiyong Gong and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Contrast Agents Based on Human Serum Albumin and Nitroxides forInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Polyphosphorhydrazone-Based Radical Dendrimers.Molecules (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shiwei GuoHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Xiaoming WangHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Yan DaiHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Xinghang DaiWest China School of Medicine Sichuan University Chengdu 610041 P. R. China.
Zhiqian LiHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Qiang LuoHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.ORCID https://orcid.org/0000-0002-3536-1485
Xiuli ZhengHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Zhongwei GuHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Hu ZhangAmgen Bioprocessing Centre Keck Graduate Institute Claremont CA 91711 USA.
Qiyong GongHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.
Kui LuoHuaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, two water-soluble PROXYL-based magnetic resonance imaging (MRI) macromolecular organic contrast agents (mORCAs) are designed and synthesized: linear and cross-linked PCE-mPEG-Ppa-PROXYL. They are prepared by conjugating linear and cross-linked poly(carboxylate ester) (PCE) with poly(ethylene glycol) (mPEG

Indexed as

branched polymersmagnetic resonance imagingmetal‐free contrast agentsnitroxidespoly(carboxylate ester)

Identifiers

PMID32714757
PMCPMC7375229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.