ArticleCureus2020
Prognostic Role of Tumor Budding in Carcinoma Tongue: A Systemic Review and Meta-Analysis.
Article in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Accumulating evidence from meta-analyses of prognostic studies on oral cancer: towards biomarker-driven patient selection.BMC cancer · 2024Pooled it
- Tumor Budding and Poor Prognosis in Oral Cancer: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2023Pooled it
- The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma.Cancer reports (Hoboken, N.J.) · 2024Article
- Survival among treated tongue cancer patients: a single-center experience.Discover oncology · 2024Article
- A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer.Journal of clinical medicine · 2024Article
- Histopathological predictors of lymph node metastasis in oral cavity squamous cell carcinoma: a systematic review and meta-analysis.Frontiers in oncology · 2024Review
- Predictive value of tumor budding in head and neck squamous cell carcinoma: an update.Virchows Archiv : an international journal of pathology · 2023Review
- Tumor Budding Should Be in Oral Cavity Cancer Reporting: A Retrospective Cohort Study Based on Tumor Microenvironment.Cancers · 2023Article
- Relationship between Tumor Budding and Partial Epithelial-Mesenchymal Transition in Head and Neck Cancer.Cancers · 2023Review
- Review
- Review
- A Novel Prognostic Stratified System Based on Tumor Budding and the Cell Nest Size in Ureter Urothelial Carcinoma.Applied bionics and biomechanics · 2022Article
- Relevance of Tumor Budding and Pattern of Invasion in Oral Squamous Cell Carcinoma.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Tumor budding is defined as a cluster of cells that invade the stroma. This has recently been studied to be associated with lymph node metastasis (LNM) and poor overall survival (OS) rate. The reliability and reproducibility of this histopathological feature make it a valid prognostic indicator in tongue carcinomas, which often have an unpredictable prognosis. The objective of this study was to group the studies that elucidate the prognostic role of tumor budding in tongue cancers. Methods A systematic database search was performed in MEDLINE, Embase, and Google Scholar for relevant studies that reported tumor budding in tongue cancer. The relevant articles were independently screened by two authors for selection and data extraction. As a result, a list of such studies, clinical trials, and references, published in English up to March 2020, was obtained, and a total of 1448 patients in nine studies were included in this meta-analysis. Statistical analysis was conducted using RevMan software 5.3 (The Nordic Cochrane Centre, Cochrane Collaboration, Copenhagen). Results A higher tumor budding score was significantly correlated with LNM (hazard ratio (HR): 3.07; 95% confidence interval (CI): 2.08-4.52; p≤.00001) and poor OS (HR: 2.40; 95% CI: 1.84-3.14; p≤.00001) in tongue cancer. Conclusions Our present study demonstrates that tumor budding is an independent predictor of LNM and OS in tongue cancer. Tumor budding should be considered a parameter in future oncological staging systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.