ArticleBDJ open2020
Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study.
Article in BDJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.Frontiers in public health · 2023Trial
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Efficacy of calcium hypophosphite toothpaste in remineralizing initial caries in vitro.BMC oral health · 2026Article
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- Bovine Cancellous Hydroxyapatite Toothpaste Enhances Enamel Remineralization.International dental journal · 2026Article
- The reinforcing effect of anti-caries treatments on acidic challenge resistance of irradiated enamel.PloS one · 2026Article
- Comparison of the remineralization effectiveness of three remineralizing agents on artificial enamel lesions: an in vitro study.BDJ open · 2025Article
- In Vitro Models Used in Cariology Mineralisation Research-A Review of the Literature.Dentistry journal · 2024Review
- Amelogenin-inspired peptide, calcium phosphate solution, fluoride and their synergistic effect on enamel biomimetic remineralization: an in vitro pH-cycling model.BMC oral health · 2024Article
- Doses of fluoride toothpaste for children up to 24 months.BDJ open · 2024Article
- Investigating salivary concentration of calcium ion in hypothyroidism.Health science reports · 2023Article
- Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review.Dentistry journal · 2023Review
- An In-Vitro Comparative Study of Fluoride Varnish and Two Calcium-Containing Fluoride Products on the Remineralization of Primary Teeth Enamel.Frontiers in dentistry · 2023Article
- Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products.Biomimetics (Basel, Switzerland) · 2022Review
- Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study.BDJ open · 2022Article
- Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions.Dentistry journal · 2022Article
- Bone Regeneration and Oxidative Stress: An Updated Overview.Antioxidants (Basel, Switzerland) · 2022Review
- Pathophysiology of Demineralization, Part I: Attrition, Erosion, Abfraction, and Noncarious Cervical Lesions.Current osteoporosis reports · 2022Review
- Prevention of Caries and Dental Erosion by Fluorides-A Critical Discussion Based on Physico-Chemical Data and Principles.Dentistry journal · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone. MATERIALS AND
methodsThree tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F
resultsPaired t-tests (baseline vs. post-Test) indicated significant (
conclusionHydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.