Sildenafil reverses the hypertrophy of mice right ventricle caused by hypoxia but does not reverse the changes in the myosin heavy chain isoforms.

Mukhallad A Aljanabi, Mahmoud A Alfaqih, Anwar Mohammad A Al-Khayat, Hameed N Bataineh

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Article in International journal of physiology, pathophysiology and pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mukhallad A AljanabiDepartment of Physiology/Faculty of MEDICINE/Jordan University of Science and Technology P.O. Box 3030, Irbid 22110, Jordan.

Mahmoud A AlfaqihDepartment of Physiology/Faculty of MEDICINE/Jordan University of Science and Technology P.O. Box 3030, Irbid 22110, Jordan.

Anwar Mohammad A Al-KhayatDepartment of Physiology/Faculty of MEDICINE/Jordan University of Science and Technology P.O. Box 3030, Irbid 22110, Jordan.

Hameed N BatainehDepartment of Physiology/Faculty of MEDICINE/Jordan University of Science and Technology P.O. Box 3030, Irbid 22110, Jordan.

Jordan University of Science and Technology · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the effect of hypoxia and concomitant sildenafil treatment on MHC isoforms in hypoxia-induced hypertrophied right ventricles. Right ventricular hypertrophy was induced in mice by exposing them to hypoxic stimulus (11% ambient oxygen) in a normobaric chamber for 20 days. 45 mice were used in this study, distributed randomly into three groups: the first group served as a control (CO), the second group was exposed to hypoxia for 20 days without sildenafil treatment (HY), and the third group was given sildenafil orally at a dose of 30 mg.kg

Indexed as

hypertrophied right ventriclehypoxiamyosin heavy chainsSildenafil

Identifiers

PMID32714496

PMCPMC7364391

OpenAlexW3046488756

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.