ArticleFrontiers in neurology2020
Valproate Use Is Associated With Posterior Cortical Thinning and Ventricular Enlargement in Epilepsy Patients.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis.Molecular psychiatry · 2026Pooled it
- Quantitative MRI Volumetry as a Potential Neuroimaging Biomarker in Levetiracetam-Treated Epilepsy.Diagnostics (Basel, Switzerland) · 2026Article
- Duration-dependent hippocampal structural changes in focal epilepsy: multicenter neuroimaging evidence.Journal of translational medicine · 2026Article
- Changes in the functional brain networks and graph theory analysis of patients with epilepsy and comorbid migraine without aura.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Higher plasma neurofilament-light chain concentration in drug-resistant epilepsy.Brain communications · 2025Article
- Accumulation of Cerebrospinal Fluid, Ventricular Enlargement, and Cerebral Folate Metabolic Errors Unify a Diverse Group of Neuropsychiatric Conditions Affecting Adult Neocortical Functions.International journal of molecular sciences · 2024Article
- A Comparison of Pre- and Post-Treatment Cranial MRI Characteristics in Patients with Pediatric Epilepsy Receiving Levetiracetam.Medicina (Kaunas, Lithuania) · 2024Article
- May anti-seizure medications alter brain structure in temporal lobe epilepsy? A prospective study.Epilepsia open · 2024Article
- The role of cranial magnetic resonance imaging findings in pediatric epilepsy: A single-center experience.Northern clinics of Istanbul · 2024Article
- Brain network changes after the first seizure: an insight into medication response?Brain communications · 2024Article
- Valproate associated brain volume-loss in pediatric epilepsy-A case series.Epilepsia open · 2023Article
- Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization.NeuroImage · 2023Review
- Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.Epilepsia · 2022Article
- The prevalence and profile of autism in Sturge-Weber syndrome.Journal of autism and developmental disorders · 2022Article
- Cortical and Subcortical Network Dysfunction in a Female Patient WithFrontiers in neurology · 2021Article
- Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Valproate is a drug widely used to treat epilepsy, bipolar disorder, and occasionally to prevent migraine headache. Despite its clinical efficacy, prenatal exposure to valproate is associated with neurodevelopmental impairments and its use in children and adults was associated with rare cases of reversible brain atrophy and ventricular enlargement. To determine whether valproate use is related with structural brain changes we examined through a cross-sectional study cortical and subcortical structures in a group of 152 people with epilepsy and a normal clinical brain MRI. Patients were grouped into those currently using valproate (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.