Evidence map›Paper›PMID 32714200›Full record

ArticleFrontiers in physiology2020

Stimulatory Role of SPAK Signaling in the Regulation of Large Conductance Ca

Ye Bi, Chunmei Li, Yiqian Zhang, Yunman Wang, Shan Chen, Qiang Yue, Robert S Hoover, Xiaonan H Wang, Eric Delpire, Douglas C Eaton and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. WNK4 kinase: from structure to physiology.American journal of physiology. Renal physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ye BiDepartment of Pediatric Nephrology, The Second Affiliated Hospital/Yuying Children Hospital, Wenzhou Medical University, Wenzhou, China.
Chunmei LiRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Yiqian ZhangDepartment of Pediatric Nephrology, The Second Affiliated Hospital/Yuying Children Hospital, Wenzhou Medical University, Wenzhou, China.
Yunman WangRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Shan ChenRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Qiang YueDepartment of Physiology, Emory University School of Medicine, Atlanta, GA, United States.
Robert S HooverRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Xiaonan H WangRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical School, Nashville, TN, United States.
Douglas C EatonRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Jieqiu ZhuangDepartment of Pediatric Nephrology, The Second Affiliated Hospital/Yuying Children Hospital, Wenzhou Medical University, Wenzhou, China.
Hui CaiRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · USWenzhou Medical University · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNUnited States Department of Veterans Affairs · USVanderbilt University · US

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Regulation of Sodium Transport in Tight EpitheliaR01DK110409 · NIDDK · EMORY UNIVERSITY · PI EATON, DOUGLAS C. · 2018 to 2021
$1.4M
BLRD VA I01 BX000994NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK110375NIDDK NIH HHS R01 DK110409
6 · The paper itself

Abstract

SPS1-related proline/alanine-rich kinase (SPAK) plays important roles in regulating the function of numerous ion channels and transporters. With-no-lysine (WNK) kinase phosphorylates SPAK kinase to active the SPAK signaling pathway. Our previous studies indicated that WNK kinases regulate the activity of the large-conductance Ca

Indexed as

BKERK and SPAK signaling pathwayhigh potassium dietlysosomal degradation pathwayubiquitination

Identifiers

PMID32714200
PMCPMC7343913
OpenAlexW3039091413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.