ArticleFrontiers in neuroscience2020
Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05964725 (The Study on Effect and Neural Network Mechanism of Transcranial Direct Current Stimulation for Sudden Deafness With Tinnitus), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Study on Effect and Neural Network Mechanism of Transcranial Direct Current Stimulation for Sudden Deafness With Tinnitus
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Whole-Brain Structural Connectivity Alterations in Chronic Subjective Tinnitus: An Exploratory Diffusion Tensor Imaging Study.Brain sciences · 2026Article
- Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus.Human brain mapping · 2024Article
- Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus.Frontiers in neurology · 2024Article
- Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model.Antioxidants (Basel, Switzerland) · 2023Article
- 𝓗Network neuroscience (Cambridge, Mass.) · 2023Article
- The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI.Frontiers in neuroscience · 2023Article
- Abnormal characterization of dynamic functional connectivity in Alzheimer's disease.Neural regeneration research · 2022Article
- Intrinsic network changes associated with cognitive impairment in patients with hearing loss and tinnitus: a resting-state functional magnetic resonance imaging study.Annals of translational medicine · 2022Article
- Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss.Brain imaging and behavior · 2022Article
- Recent-onset and persistent tinnitus: Uncovering the differences in brain activities using resting-state functional magnetic resonance imaging technologies.Frontiers in neuroscience · 2022Article
- Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss.Frontiers in aging neuroscience · 2022Article
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
- Functional Magnetic Resonance Imaging Reveals Early Connectivity Changes in the Auditory and Vestibular Cortices in Idiopathic Sudden Sensorineural Hearing Loss With Vertigo: A Pilot Study.Frontiers in human neuroscience · 2021Article
- Surface-Based Amplitude of Low-Frequency Fluctuation Alterations in Patients With Tinnitus Before and After Sound Therapy: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Objective Recognition of Tinnitus Location Using Electroencephalography Connectivity Features.Frontiers in neuroscience · 2021Article
- Aberrant Frequency Related Change-Detection Activity in Chronic Tinnitus.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss.
methodsAcute tinnitus patients (
resultsCompared with healthy subjects, acute tinnitus patients had a general reduction in FC between auditory and non-auditory brain regions. Based on FC analysis, the superior temporal gyrus (STG) revealed reduced undirected connectivity with non-auditory brain regions including the amygdala (AMYG), nucleus accumbens (NAc), the cerebellum, and postcentral gyrus (PoCG). Using the GCA algorithm, increased effective connectivity from the right AMYG to the right STG, and reduced connectivity from the right PoCG to the left NAc was observed in acute tinnitus patients with hearing loss. The pure-tone threshold was positively correlated with FC between the AMYG and STG, and negatively correlated with FC between the left NAc and the right PoCG. In addition, a negative association between the GCA value from the right PoCG to the left NAc and the THI scores was observed.
conclusionAcute tinnitus patients have aberrant FC strength and causal connectivity in both the auditory and non-auditory cortex, especially in the STG, AMYG, and NAc. The current findings will provide a new perspective for understanding the neuropathophysiological mechanism in acute tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.