Evidence map›Paper›PMID 32714072›Full record

ArticleInternational journal of medical sciences2020

TGFβ1 induces bone formation from BMP9-activated Bone Mesenchymal Stem Cells, with possible involvement of non-canonical pathways.

Huan Yao, Yulong Zou, Ke Yang, Liangjun Yin, Yang Liu, Ruidong Li

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Article
  7. Recovering Osteoblast Functionality on TiOInternational journal of nanomedicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Huan YaoThe First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yulong ZouDepartment of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ke YangThe Children's Hospital, Chongqing Medical University, Chongqing, China.
Liangjun YinDepartment of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yang LiuDepartment of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ruidong LiDepartment of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Dalian Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reconstruction of bone defects is one of the most substantial and difficult clinical challenges in orthopedics. Transforming growth factor beta 1 (TGFβ1) might play an important role in stimulating osteogenic differentiation of bone morphogenetic protein 9 (BMP9)-induced C3H10T1/2 mesenchymal stem cells. In our current study, we examined the potential synergy between TGFβ1 and BMP9 in promoting the osteogenesis of C3H10T1/2 cells, and whether such effects could contribute to bone formation

Indexed as

AnimalsCalcification, PhysiologicCell DifferentiationCell LineGene Expression Regulation, DevelopmentalGrowth Differentiation Factor 2HSP47 Heat-Shock ProteinsHumansMesenchymal Stem CellsMiceOsteogenesisPhosphorylationSignal TransductionTransforming Growth Factor beta1Gdf2 protein, mouseGrowth Differentiation Factor 2HSP47 Heat-Shock ProteinsSerpinh1 protein, mouseTgfb1 protein, mouseTransforming Growth Factor beta1BMP9Bone mesenchymal stem cellHSP47OsteogenesisTGFβ1

Identifiers

PMID32714072
PMCPMC7378670
OpenAlexW3038513393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.