ArticleJournal of diabetes and its complications2020
Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study.
Article in Journal of diabetes and its complications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The simplified method for quantifying metabolic syndrome (siMS) score reflects an increased cardiometabolic burden: adiposity, hemodynamics, and HRV findings in young adults.Journal of diabetes and metabolic disorders · 2026Article
- High predicted cardiac event risk in youth with obesity and type 2 diabetes: a pooled cohort analysis.Cardiovascular diabetology · 2025Article
- Review
- D1S-Neuro Program: Frequency and Risk Factors for the Development of Diabetic Neuropathy in Pediatric Patients with Type 1 Diabetes Mellitus, a Single Center Study.Biomedicines · 2024Article
- Retinal Microvascular Changes in Association with Endothelial Glycocalyx Damage and Arterial Stiffness in Patients with Diabetes Mellitus Type 2: A Cross-Sectional Study in a Greek Population.Journal of personalized medicine · 2024Article
- Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.Circulation research · 2024Observational
- Association of Elevated Arterial Stiffness With Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study.Diabetes care · 2023Article
- Heart rate variability behavior in young men after short-term carotenoid-containing supplementation.Heliyon · 2023Article
- Relationship between reduced heart rate variability and increased arterial stiffness evaluated by the cardio-ankle vascular index in people with type 2 diabetes.Diabetology international · 2023Article
- Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study.Diabetes care · 2022Article
- Unique Cardiovascular Disease Risk Factors in Hispanic Individuals.Current cardiovascular risk reports · 2022Review
- Association between Cardiac Autonomic Neuropathy and Coronary Artery Lesions in Patients with Type 2 Diabetes.Disease markers · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimsTo evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness.
methodsWe studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth Study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV.
resultsParticipants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDLC). Participants with T2D and arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p < 0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = -1.11, p = 0.08).
conclusionsYouth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.
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