ReviewSexual medicine reviews2020
Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men.
Review in Sexual medicine reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Correlation between viral infections in male semen and infertility: a literature review.Virology journal · 2024Review
- Antiviral activity of sulphated specialized metabolites from sea urchinRSC advances · 2024Article
- Update on known and emergent viruses affecting human male genital tract and fertility.Basic and clinical andrology · 2024Review
- What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.Frontiers in reproductive health · 2024Review
- Human seminal virome: a panel based on recent literature.Basic and clinical andrology · 2022Review
- Review
- Effects of SARS CoV-2, COVID-19, and its vaccines on male sexual health and reproduction: where do we stand?International journal of impotence research · 2022Review
- Male Sexual Health Implications of the 2022 Global Monkeypox Outbreak.Research and reports in urology · 2022Review
- COVID-19 may affect male fertility but is not sexually transmitted: a systematic review.F&S reviews · 2021Review
- Presence of SARS-CoV-2 RNA in Semen-Cohort Study in the United States COVID-19 Positive Patients.Infectious disease reports · 2021Article
- The impact of COVID-19 on the male reproductive tract and fertility: A systematic review.Arab journal of urology · 2021Review
- Viral infections and implications for male reproductive health.Asian journal of andrologyArticle
- COVID-19 and Male Reproduction: A Thorny Problem.American journal of men's healthArticle
- Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe 21st century has seen a series of viral pandemics that have collectively infected millions of individuals. To understand factors that may contribute to viral spread and address long-term health sequelae for survivors, it is important to review evidence regarding viral presence in semen, sexual transmission potential, and possible effects on fertility.
aimTo review the current literature regarding the sexual transmissibility of recent viral pandemics and their effects on semen parameters and fertility. We review evidence for the following viruses: Ebola, Zika, West Nile, pandemic influenza, severe acute respiratory syndrome (SARS), and SARS-corona virus-2 (SARS-CoV-2).
methodsA literature search was conducted to identify relevant studies. Titles and abstracts were reviewed for relevance. References from identified articles were searched and included, if appropriate.
main outcome measuresThe main outcome measure of this study was reviewing of peer-reviewed literature.
resultsBoth the Ebola virus and Zika virus are present in semen, but only the Zika virus shows consistent evidence of sexual transmission. Current evidence does not support the presence of the West Nile virus, pandemic influenza, SARS, and SARS-CoV-2 in semen. The Zika virus appears to alter semen parameters in a way that diminishes fertility, but the effect is likely time limited. The West Nile virus and SARS have been associated with orchitis in a small number of case reports. Viruses that cause febrile illness, such as pandemic influenza, SARS, and SARS-CoV-2, are associated with decreased sperm count and motility and abnormal morphology. SARS and SARS-CoV-2 may interact with angiotensin-converting enzyme 2 receptors present in the testes, which could impact spermatogenesis.
conclusionsWe have reported the presence in semen, sexual transmission potential, and fertility side effects of recent viral pandemics. Overall, semen studies and fertility effects are highly understudied in viral pandemics, and rigorous study on these topics should be undertaken as novel pandemics emerge. Payne K, Kenny P, Scovell JM, et al. Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications for Men. Sex Med Rev 2020;8:518-530.
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