ArticleHypertension (Dallas, Tex. : 1979)2020
Isolated Diastolic Hypertension in the UK Biobank: Comparison of ACC/AHA and ESC/NICE Guideline Definitions.
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis.European heart journal · 2026Pooled it
- A cohort study and meta-analysis of isolated diastolic hypertension: searching for a threshold to guide treatment.European heart journal · 2021Pooled it
- Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants.Frontiers in cardiovascular medicine · 2021Pooled it
- Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure.Journal of the American Heart Association · 2024Trial
- Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Association analysis of blood pressure with incident risks for thoracic and abdominal aortic aneurysms: an observational study of the UK Biobank cohort.Open heart · 2025Observational
- Adverse Cardiovascular Events Are Infrequent but Significantly Associated With Systolic and Pre-Systolic Hypertension: An Occupational Cohort Study.Cardiology research · 2025Article
- Association between cardiovascular risk and diastolic blood pressure in older adults with systolic blood pressure less than 130mmHg: a prospective cohort study from 2014 to 2022.Aging clinical and experimental research · 2024Article
- Prevalence and Characteristics of Isolated Nighttime Masked Uncontrolled Hypertension in Treated Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Isolated diastolic hypertension and cardiovascular outcomes across different diagnostic guidelines: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Article
- Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension-Con Side of the Argument.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Isolated diastolic hypertension is not associated with endothelial dysfunction.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Prevalence, Predictors, Progression, and Prognosis of Hypertension Subtypes in the Framingham Heart Study.Journal of the American Heart Association · 2022Article
- Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study.Frontiers in oncology · 2022Article
- Association of isolated diastolic hypertension based on different guideline definitions with incident cardiovascular risk in a Chinese rural cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Associations of the Cardiometabolic Index with the Risk of Cardiovascular Disease in Patients with Hypertension and Obstructive Sleep Apnea: Results of a Longitudinal Cohort Study.Oxidative medicine and cellular longevity · 2022Article
- Hypertension Subtypes, Mortality Risk, and Differential Effects Between Two Hypertension Guidelines.Frontiers in medicine · 2022Article
- The total and direct effects of systolic and diastolic blood pressure on cardiovascular disease and longevity using Mendelian randomisation.Scientific reports · 2021Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The 2017 American College of Cardiology/American Heart Association guideline defines hypertension as a blood pressure ≥130/80 mm Hg, whereas the 2018 European Society of Cardiology (ESC) and 2019 National Institute for Health and Care Excellence (NICE) guidelines use a ≥140/90 mm Hg threshold. Our objective was to study the associations between isolated diastolic hypertension (IDH), diagnosed using these 2 blood pressure thresholds, and cardiovascular disease (CVD) in a large cohort of UK adults. We analyzed data from UK Biobank, which enrolled participants between 2006 and 2010 with follow-up through March 2019. We excluded persons with systolic hypertension or baseline CVD. We defined incident CVD as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. We used Cox regression to quantify associations between IDH and CVD, as well as the individual outcomes included in the composite outcome. We studied 151 831 participants with normal systolic blood pressure (mean age 54 years, 40% male). Overall, 24.5% had IDH by the American College of Cardiology/American Heart Association definition compared with 6% by the ESC/NICE definition. Compared with normal diastolic blood pressure, IDH by the American College of Cardiology/American Heart Association definition was not significantly associated with CVD risk (hazard ratio, 1.08 [95% CI, 0.98-1.18]) whereas IDH by the ESC/NICE definition was significantly associated with a modest increase in CVD (hazard ratio, 1.15 [95% CI, 1.04-1.29]). Similar results were found by sex and among participants not taking baseline antihypertensives. Furthermore, neither IDH definition was associated with the individual outcomes of nonfatal myocardial infarction or stroke. In conclusion, the proportion of UK Biobank participants with IDH was significantly higher by the American College of Cardiology/American Heart Association definition compared with the ESC/NICE definitions; however, only the ESC/NICE definition was statistically associated with increased CVD risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.