Evidence map›Paper›PMID 32713274›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Fibrinogen-Like Protein 2-Associated Transcriptional and Histopathological Features of Immunological Preeclampsia.

Pascale Robineau-Charette, David Grynspan, Samantha J Benton, Jeremiah Gaudet, Brian J Cox, Barbara C Vanderhyden, Shannon A Bainbridge

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pascale Robineau-CharetteFrom the Department of Cellular and Molecular Medicine (P.R.-C., S.J.B, B.C.V., S.A.B.), University of Ottawa, ON, Canada.
David GrynspanDepartment of Pathology and Laboratory Medicine (D.G.), University of Ottawa, ON, Canada.
Samantha J BentonFrom the Department of Cellular and Molecular Medicine (P.R.-C., S.J.B, B.C.V., S.A.B.), University of Ottawa, ON, Canada.
Jeremiah GaudetFaculty of Medicine and Interdisciplinary School of Health Sciences, Faculty of Health Sciences (J.G., S.A.B.), University of Ottawa, ON, Canada.
Brian J CoxDepartment of Physiology (B.J.C.), Faculty of Medicine, University of Toronto, ON, Canada.
Barbara C VanderhydenFrom the Department of Cellular and Molecular Medicine (P.R.-C., S.J.B, B.C.V., S.A.B.), University of Ottawa, ON, Canada.
Shannon A BainbridgeFrom the Department of Cellular and Molecular Medicine (P.R.-C., S.J.B, B.C.V., S.A.B.), University of Ottawa, ON, Canada.
University of Ottawa · CAUniversity of Toronto · CA

Funding

CIHR 130543
6 · The paper itself

Abstract

Preeclampsia is a multifactorial hypertensive disorder of pregnancy, with variable presentation in both maternal and fetal factors, such that no treatment or marker is currently universal to all cases. Here, we demonstrate that the prothrombinase and immunomodulatory secreted factor FGL-2 (fibrinogen-like protein 2) is differentially expressed across previously characterized gene expression clusters containing clinically relevant disease subtypes.

Indexed as

PlacentaPre-EclampsiaBiomarkersEndoglinFemaleFibrinogenGene Expression ProfilingGene Expression RegulationHumansImmunityInterferon-gammaPhylogenyPlacenta DiseasesPregnancyTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Receptor-1BiomarkersEndoglinFGL2 protein, humanFibrinogenInterferon-gammaTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Receptor-1chorionic villifibrinhistologyinflammationplacentapreeclampsia

Identifiers

PMID32713274
PMCPMC7418930
OpenAlexW3045013411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.