Evidence map›Paper›PMID 32713100›Full record

ArticleJournal of occupational health2020

Simple and reliable method to simultaneously determine urinary 1- and 2-naphthol using in situ derivatization and gas chromatography-mass spectrometry for biological monitoring of naphthalene exposure in occupational health practice.

Akito Takeuchi, Sadao Nakamura, Akira Namera, Tomoaki Kondo, Hiroyuki Onuki, Shinobu Yamamoto, Shingo Okamura, Osamu Nishinoiri, Yoko Endo, Hiroyuki Miyauchi and 1 more

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Akito TakeuchiOsaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka, Japan.ORCID https://orcid.org/0000-0003-1782-6565
Sadao NakamuraAgilent Technologies Japan, Ltd., Tokyo, Japan.
Akira NameraDepartment of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tomoaki KondoGlobal Application Development Center, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan.
Hiroyuki OnukiCollege of Science, Rikkyo University, Tokyo, Japan.
Shinobu YamamotoDepartment of Environmental Measurement and Control, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID https://orcid.org/0000-0002-0523-1794
Shingo OkamuraOsaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka, Japan.
Osamu NishinoiriOsaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka, Japan.
Yoko EndoEndo Occupational Health Consultant Office, Osaka, Japan.
Hiroyuki MiyauchiDepartment of Environmental Measurement and Control, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ginji EndoOsaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka, Japan.
Japan Industrial Safety and Health Association · JPUniversity of Occupational and Environmental Health Japan · JPAgilent Technologies (Japan) · JPHiroshima University · JPRikkyo University · JPShimadzu (Japan) · JP

Funding

Japan Industrial Safety and Health Association
6 · The paper itself

Abstract

objectivesThe aim of this study was to develop and validate a simple and reliable gas chromatography-mass spectrometry (GC-MS) method to simultaneously determine urinary 1-naphthol (1-NAP) and 2-naphthol (2-NAP) for biological monitoring of occupational exposure to naphthalene.

methodsNAPs were derivatized in situ with acetic anhydride after enzymatic hydrolysis, extracted with n-hexane, and analyzed using GC-MS. Validation of the proposed method was conducted in accordance with US Food and Drug Administration guidance. A final validation was performed by analyzing a ClinChek

resultsThe linearity of calibration curves was indicated by a high correlation coefficient (>0.999) in the concentration range 1-100 μg/L for each NAP. The limits of detection and quantification for each NAP were 0.30 and 1.00 μg/L, respectively. The recovery was 90.8%-98.1%. The intraday and interday accuracies, expressed as the deviation from the nominal value, were 92.2%-99.9% and 93.4%-99.9%, respectively. The intraday and interday precision, expressed as the relative standard deviation, was 0.3%-3.9% and 0.4%-4.1%, respectively. The ClinChek

conclusionsThe proposed method is simple, reliable, and appropriate for routine analyses, and is useful for biological monitoring of naphthalene exposure in occupational health practice.

Indexed as

Biological MonitoringGas Chromatography-Mass SpectrometryHumansNaphtholsOccupational Exposure1-naphthol2-naphtholNaphtholsbiological monitoringgas chromatography-mass spectrometrynaphthalenenaphtholoccupational exposureurine

Identifiers

PMID32713100
PMCPMC7382817
OpenAlexW3044333227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.