ArticleHead and neck pathology2021
The Histological Basis of Frank's Sign.
Article in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- More Than a Wrinkle: The Burden of Franck's Sign.Journal of general internal medicine · 2026Article
- Association of Diagonal Earlobe Crease (Frank's Sign) with Intracranial Aneurysm Rupture at Small Sizes.Brain sciences · 2026Article
- Frank's Sign and Risk of Cardiovascular Events in Patients Hospitalized for Pneumonia: A Prospective Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- A new clinical examination finding in obstructive sleep apnea; diagonal auricular fold (Frank sign).Sleep & breathing = Schlaf & Atmung · 2026Article
- TyHGB combined with diagonal earlobe crease and traditional risk factors for constructing a diagnostic model of coronary heart disease.Lipids in health and disease · 2026Article
- Diagnostic model for angiographic obstructive coronary artery disease combining CHG, DELC, and traditional risk factors: a bootstrap validation study.Frontiers in endocrinology · 2026Article
- Clinical characteristics of subclinical carotid atherosclerosis in middle-aged and elderly populations with different glucose metabolism statuses: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Frank's Sign as a Dose-Dependent Marker of White Matter Burden in CADASIL: A Brain MRI Study.Journal of clinical medicine · 2025Article
- Diagnostic value of the diagonal earlobe crease in combination with lipoprotein(a) in coronary heart disease.Scientific reports · 2025Article
- Article
- Prevalence of Frank's sign in healthy young individuals, morphological characteristics, and its association with family history of chronic disease.Forensic science, medicine, and pathology · 2024Article
- Association of advanced glycation end products with ear lobe crease: A cross-sectional study.Journal of diabetes · 2024Article
- Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease.International journal of general medicine · 2024Article
- The Relationship between the Presence of an Earlobe Crease and Overactive Bladder: A Cross-Sectional Case-Controlled Study.Medicina (Kaunas, Lithuania) · 2023Article
- Unified Anatomical Explanation of Diagonal Earlobe Creases, Preauricular Creases, and Paired Creases of the Helix.Cureus · 2022Article
- The importance of inspection in clinical cardiology: Frank's sign.Clinical case reports · 2022Article
- The prognostic value of the Frank sign.Forensic science, medicine, and pathology · 2022Article
- Frank's sign and paired ear creases of the helix : Current concepts of significance for morbidity.Wiener klinische Wochenschrift · 2022Review
- What do Steven Spielberg, Mel Gibson and Emperor Hadrian have in common? Frank's sign and the link with coronary artery disease.Oxford medical case reports · 2021Article
- Diagonal Earlobe Crease (Frank's Sign) for Diagnosis of Coronary Artery Disease: A Systematic Review of Diagnostic Test Accuracy Studies.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frank's sign is a diagonal crease of the ear lobe, supposedly related to cardiac pathology, and has strongly been associated with coronary artery atherosclerosis. A total of 45 consecutive adult patients referred for autopsy in a one-and-a-half-year period were extensively studied. Samples from both the ear lobes were obtained for histopathology, as well as cardiac samples from all four cardiac compartments. When compared patients with Frank's sign and those without it had no statistical difference in age (p = 0.0575). There was however a statistically significant increased cardiac weight (p = 0.0005), left ventricular wall thickness (p = 0.0002), and right ventricular wall thickness (p = 0.0043). Histopathology obtained from the ear lobes revealed myoelastofibrosis in an arterial vessel, located at the base of the crease, diffuse fibrosis, and Wallerian-like degeneration, with eosinophilic inclusions in the peripheral nerves. These changes suggest a time-related progression of the crease-associated changes. Our data suggest a significant correlation between the morphological changes of the myocardium and the presence of the ear lobe creases, with arterial myoelastofibrosis, Wallerian-like degeneration in peripheral nerves and deep tissue fibrosis found in the base of the crease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.