ArticleEndocrine2021
Predictors of healing, ulcer recurrence and persistence, amputation and mortality in type 2 diabetic patients with diabetic foot: a 10-year retrospective cohort study.
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Risk factors associated with the recurrence of diabetic foot ulcers: A meta-analysis.PloS one · 2025Pooled it
- The incidence of lower extremity amputation and its associated risk factors in patients with diabetic foot ulcers: A meta-analysis.International wound journal · 2024Pooled it
- [Construction and preliminary validation of a risk prediction model for the recurrence of diabetic foot ulcer in diabetic patients].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Pooled it
- Effect of diabetic foot ulcers and other risk factors on the prevalence of lower extremity amputation: A meta-analysis.International wound journal · 2023Pooled it
- Influencing factors for the recurrence of diabetic foot ulcers: A meta-analysis.International wound journal · 2023Pooled it
- [A prospective randomized controlled study of antibiotic bone cement in the treatment of diabetic foot ulcer].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Trial
- Translational development of ABCB5Stem cell research & therapy · 2022Trial
- Anemia, Glycemia, and Inflammation in PAD-Related Tissue Necrosis.Metabolites · 2026Article
- Long-Term Mortality in Diabetic Foot Disease is Higher Than That of Overall Cancer: Results From Three International Cohorts.Diabetes/metabolism research and reviews · 2026Article
- Excess risk of cardiovascular disease and mortality after amputation in type 2 diabetes: a nationwide population study from the Swedish National Diabetes Register.Cardiovascular diabetology · 2026Observational
- Diabetic foot ulcer-related amputation is associated with twofold increased risk of cardiovascular disease: A Korean National Health Information Database Study.Journal of diabetes investigation · 2026Article
- Relationship between low phase angle and impaired healing of diabetic foot ulcer: a retrospective cohort study.Nutrition & metabolism · 2026Article
- Rethinking diabetic foot ulcer care: Integrating exercise and physical activity.Journal of diabetes and its complications · 2026Review
- Mortality predictors and survival nomogram for hospitalized diabetic foot patients: a decade-long cohort.Frontiers in endocrinology · 2026Article
- C-reactive protein-to-albumin ratio improves prediction of 6-month major adverse limb events in diabetic foot ulcers: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Cathepsin B as a potential serum biomarker for early diagnosis and progression of diabetic foot ulcer complicated with peripheral vascular disease.Scientific reports · 2025Article
- Interpretable machine learning model for predicting recurrence in patients with diabetic foot ulcers.BMJ open diabetes research & care · 2025Article
- Major Common Hallmarks and Potential Epigenetic Drivers of Wound Chronicity and Recurrence: Hypothesis and Reflections.International journal of molecular sciences · 2025Review
- High Transepidermal Water Loss at the Site of Wound Closure Is Associated With Increased Recurrence of Diabetic Foot Ulcers: The NIDDK Diabetic Foot Consortium TEWL Study.Diabetes care · 2025Article
- Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers.Diabetologia · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePredictors of outcome of diabetic foot ulcer (DFU) are important to improve the management of patients. Aim of the study was to find these predictors in type 2 diabetic patients with DFU.
methodsWe recruited 583 patients. They were followed-up by a multidisciplinary team. A holistic and conservative approach was used and all risk factors and co-morbidities were aggressively treated.
resultsDuring the follow-up period, 79.6% of patients healed in a mean time of 7.6 ± 3.8 months, 6.9% showed DFU persistence, 9.9% had minor amputations, and 3.6% experienced major amputation. Seventeen percent of the patients died. Among patients who healed, 37.1% of them showed DFU recurrence. Impairment of renal function was associated to DFU persistence, amputation, and mortality. Previous cardiovascular disease predicted DFU persistence, DFU recurrence, and mortality. Lower BMI predicted DFU persistence and mortality. Osteomyelitis was a predictor of amputation and death. Markers of peripheral artery disease (PAD) predicted minor amputation and DFU recurrence. Our study shows a relatively low incidence of complications of DFU.
conclusionsSome predictors of outcome of DFU were confirmed and new predictors, like BMI and markers of PAD, were found. Our new findings suggest future strategies for nutrition support and revascularization. In addition, a holistic and conservative approach may improve the prognosis.
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