ArticleIntensive care medicine experimental2020
The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation.
Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of Different Ventilation Rates on Resuscitation in a Porcine Ventricular Fibrillation Cardiac Arrest Model.Shock (Augusta, Ga.) · 2026Article
- Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model.Intensive care medicine experimental · 2026Article
- Article
- Inter-rater reliability of point-of-care ultrasound during out-of-hospital cardiac arrest: an ancillary analysis of the observational prospective ACE trial.Resuscitation plus · 2026Article
- A multimodal characterization of cardiopulmonary resuscitation-associated lung edema.Intensive care medicine experimental · 2024Article
- Detecting Intrathoracic Airway Closure during Prehospital Cardiopulmonary Resuscitation Using Quasi-Static Pressure-Volume Curves: A Pilot Study.Journal of clinical medicine · 2024Article
- Oxygenation and ventilation during prolonged experimental cardiopulmonary resuscitation with either continuous or 30:2 compression-to-ventilation ratios together with 10 cmHIntensive care medicine experimental · 2024Article
- Effects of positive end-expiratory pressure on brain oxygenation, systemic oxygen cascade and metabolism in acute brain injured patients: a pilot physiological cross-sectional study.Journal of clinical monitoring and computing · 2024Observational
- Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation.Intensive care medicine experimental · 2023Article
- Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease.Critical care (London, England) · 2022Article
- High PEEP Levels during CPR Improve Ventilation without Deleterious Haemodynamic Effects in Pigs.Journal of clinical medicine · 2022Article
- Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model.Intensive care medicine experimental · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPositive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect of PEEP on cardiac output during cardiopulmonary resuscitation (CPR) is not known.
methodsThis was a preclinical randomized, controlled, animal study conducted in an animal research facility on 25 Landrace-Yorkshire pigs. After inducing cardiac arrest, CPR was performed with LUCAS 3. During CPR, pigs were ventilated at a PEEP of 0, 5, 10, 15, 20 cmH
resultsA mixed-effects repeated-measures analysis of variance was used to compare the baseline value adjusted mean cardiac output, PaO
conclusionsA PEEP of 0-5 resulted in the optimal oxygen delivery and cardiac output during CPR, with PEEP of 5 resulting in higher oxygen delivery, and a slightly lower, statistically insignificant cardiac output than PEEP of 0.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.