ArticleNeuropsychobiology2021
Impaired Cognitive Flexibility and Working Memory Precedes Depression: A Rat Model to Study Depression.
Article in Neuropsychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Microbial modulators of the mind: probiotic interventions in hippocampal neurogenesis and cognitive flexibility.Antonie van Leeuwenhoek · 2025Review
- Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration.Psychedelics · 2025Article
- How does chronic unpredictable mild stress affect the number of mature oocytes? An experimental study.International journal of reproductive biomedicine · 2025Article
- Rhythmic modulation of dorsal hippocampus across distinct behavioral timescales during spatial set-shifting.bioRxiv : the preprint server for biology · 2025Article
- Temporal Dynamics of Social Anxiety and Depressive Symptoms: The Moderating Role of Cognitive Flexibility.Depression and anxiety · 2025Article
- PM2.5 Exposure Triggers Hypothalamic Oxidative and ER Stress Leading to Depressive-like Behaviors in Rats.International journal of molecular sciences · 2024Article
- From antidepressants and psychotherapy to oxytocin, vagus nerve stimulation, ketamine and psychedelics: how established and novel treatments can improve social functioning in major depression.Frontiers in psychiatry · 2024Review
- Identifying the most crucial factors associated with depression based on interpretable machine learning: a case study from CHARLS.Frontiers in psychology · 2024Article
- Article
- Psychological dominant stressor modification to an animal model of depression with chronic unpredictable mild stress.Veterinary world · 2023Article
- The Ripple Effect: Unveiling the Bidirectional Relationship Between Negative Life Events and Depressive Symptoms in Medical Cadets.Psychology research and behavior management · 2023Article
- Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor.Neurochemical research · 2022Article
- The neural correlates of interference control dysfunction of working memory in major depressive disorder: An event-related potential study.Frontiers in psychiatry · 2022Article
- Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.Translational psychiatry · 2021Article
- Effect of solution focused group therapy on depressive symptoms and cognitive flexibility of depressive disorder patient.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
- Effects of aerobic exercise on cognitive function in adults with major depressive disorder: A systematic review and meta-analysis.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDepressive disorders are the 4th leading cause of health problems and the 2nd leading cause of burden among all diseases. Almost all depressive disorder patients have cognitive impairments to a certain extend. Studies about cognitive impairments in depression had been conducted, but whether cognitive dysfunctions are the cause or the effect is still not clear.
objectivesTo analyze the process of working memory and cognitive flexibility impairments in a rat model of depression.
methodsIn this experimental study, chronic unpredictable mild stress (CUMS) was used as a model of depression in 30 rats (Rattus novergicus). Cognitive function was assessed with the Morris water maze and attentional set shifting test.
resultsThis study found a significant difference on day 21 in working memory (p = 0.002) and cognitive flexibility (p = 0.036), which continued to day 41 in working memory (p = 0.001) and cognitive flexibility (p = 0.020). In the CUMS model of depression, parameters peak on day 41 and reveal parameter changes in weight gain (p = 0.018), food intake (p < 0.001), changes in food intake (p = 0.001), and the sucrose preference (p = 0.005), elevated plus maze (p = 0.001), and light dark box tests (p = 0.020).
conclusionIn a rat model of depression, cognitive impairment preceded depression, but it might be caused by anxiety-like behavior that occurred in early stimulation of chronic unpredictable mild stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.