Evidence map›Paper›PMID 32712582›Full record

ArticleRespiratory care2020

PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response.

Vitaly O Kheyfets, Steven R Lammers, Jennifer Wagner, Karsten Bartels, Jerome Piccoli, Bradford J Smith

Abstract read
In one paragraph

Article in Respiratory care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vitaly O KheyfetsDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. vitaly.kheyfets@cuanschutz.edu.
Steven R LammersDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Jennifer WagnerDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.
Karsten BartelsDepartment of Anesthesiology, Psychiatry, Medicine, and Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Jerome PiccoliUniversity of Colorado School of Medicine, Aurora, Colorado.
Bradford J SmithDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

Funding

Improving Opioid Prescription Safety After SurgeryK23DA040923 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BARTELS, KARSTEN · 2016 to 2020
$945k
The Importance of Inhomogeneity in the Pathogenesis of Lung InjuryR00HL128944 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SMITH, BRADFORD J · 2017 to 2019
$747k
Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertensionK25HL133481 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KHEYFETS, VITALY · 2017 to 2021
$605k
NHLBI NIH HHS K25 HL133481NHLBI NIH HHS R00 HL128944NIDA NIH HHS K23 DA040923
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic is creating ventilator shortages in many countries that is sparking a conversation about placing multiple patients on a single ventilator. However, on March 26, 2020, six leading medical organizations released a joint statement warning clinicians that attempting this technique could lead to poor outcomes and high mortality. Nevertheless, hospitals around the United States and abroad are considering this technique out of desperation (eg, New York), but there is little data to guide their approach. The overall objective of this study is to utilize a computational model of mechanically ventilated lungs to assess how patient-specific lung mechanics and ventilator settings impact lung tidal volume (V

methodsWe developed a lumped-parameter computational model of multiple patients connected to a shared ventilator and validated it against a similar experimental study. We used this model to evaluate how patient-specific lung compliance and resistance would impact V

resultsOur computational model predicts V

conclusionsAssigning patients to preset ventilators based on their required level of support on the lower PEEP/higher [Formula: see text] scale of the National Institute of Health's National Heart, Lung, and Blood Institute ARDS Clinical Network (ARDSNet), secondary to lung mechanics, could be used to overcome some of the legitimate concerns of placing multiple patients on a single ventilator. We emphasize that our results are currently based on a computational model that has not been validated against any preclinical or clinical data. Therefore, clinicians considering this approach should not look to our study as an exact estimate of predicted patient V

Indexed as

AlgorithmsBetacoronavirusComputer SimulationCoronavirus InfectionsCOVID-19HumansPandemicsPneumonia, ViralPositive-Pressure RespirationProof of Concept StudyRespiratory MechanicsSARS-CoV-2Ventilators, MechanicalCOVID-19mass-casualtymechanical ventilationrespiratory failureventilator-induced lung injury

Identifiers

PMID32712582
PMCPMC7538006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.