Evidence map›Paper›PMID 32712343›Full record

ArticleBrain stimulation

Distinct perceptive pathways selected with tonic and bursting patterns of thalamic stimulation.

Matthew S Willsey, Charles W Lu, Sam R Nason, Karlo A Malaga, Scott F Lempka, Cynthia A Chestek, Parag G Patil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Spinal Cord Stimulation for Painful Diabetic Neuropathy.Journal of diabetes science and technology · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew S WillseyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: mwillsey@umich.edu.
Charles W LuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Sam R NasonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Karlo A MalagaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, Bucknell University, Lewisburg, PA, USA.
Scott F LempkaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
Cynthia A ChestekDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Electrical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Robotics Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Parag G PatilDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: pgpatil@umich.edu.

Funding

TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0M
Frontoparietal Mechanisms of Anesthetic-induced UnconsciousnessR01GM098578 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEE, UNCHEOL, MASHOUR, GEORGE ALEXANDER · 2012 to 2019
$2.4M
Regenerative Peripheral Nerve Interface for Restoring Individual Finger Movement in People with Upper Limb AmputationsR01NS105132 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHESTEK, CYNTHIA ANNE · 2018 to 2022
$2.1M
NIGMS NIH HHS R01 GM098578NINDS NIH HHS R01 NS105132NINDS NIH HHS T32 NS007222
6 · The paper itself

Abstract

backgroundNovel patterns of electrical stimulation of the brain and spinal cord hold tremendous promise to improve neuromodulation therapies for diverse disorders, including tremor and pain. To date, there are limited numbers of experimental studies in human subjects to help explain how stimulation patterns impact the clinical response, especially with deep brain stimulation. We propose using novel stimulation patterns during electrical stimulation of somatosensory thalamus in awake deep brain stimulation surgeries and hypothesize that stimulation patterns will influence the sensory percept without moving the electrode.

methodsIn this study of 15 fully awake patients, the threshold of perception as well as perceptual characteristics were compared for tonic (trains of regularly-repeated pulses) and bursting stimulation patterns.

resultsIn a majority of subjects, tonic and burst percepts were located in separate, non-overlapping body regions (i.e., face vs. hand) without moving the stimulating electrode (p < 0.001; binomial test). The qualitative features of burst percepts also differed from those of tonic-evoked percepts as burst patterns were less likely to evoke percepts described as tingling (p = 0.013; Fisher's exact test).

conclusionsBecause somatosensory thalamus is somatotopically organized, percept location can be related to anatomic thalamocortical pathways. Thus, stimulation pattern may provide a mechanism to select for different thalamocortical pathways. This added control could lead to improvements in neuromodulation - such as improved efficacy and side effect attenuation - and may also improve localization for sensory prostheses.

Indexed as

AdultDeep Brain StimulationEssential TremorFemaleHumansMaleNeural PathwaysPerceptionThalamusTouchWakefulnessBurstDeep brain stimulationMovement disordersPerceptionThalamus

Identifiers

PMID32712343
PMCPMC10788093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.