ArticleInternational journal of antimicrobial agents2020
Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients.
Article in International journal of antimicrobial agents, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 6 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- D-dimer, disease severity, and deaths (3D-study) in patients with COVID-19: a systematic review and meta-analysis of 100 studies.Scientific reports · 2021Pooled it
- Delirium is a good predictor for poor outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review, meta-analysis, and meta-regression.Journal of psychiatric research · 2021Pooled it
- Nervous system diseases are associated with the severity and mortality of patients with COVID-19: a systematic review and meta-analysis.Epidemiology and infection · 2021Pooled it
- Clinical Significance of Plasma D-Dimer in COVID-19 Mortality.Frontiers in medicine · 2021Pooled it
- Pooled it
- Diagnostic Value of D-Dimer in COVID-19: A Meta-Analysis and Meta-Regression.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Effects of L-carnitine supplementation in patients with mild-to-moderate COVID-19 disease: a pilot study.Pharmacological reports : PR · 2022Trial
- An early novel prognostic model for predicting 80-day survival of patients with COVID-19.Frontiers in cellular and infection microbiology · 2022Trial
- Admission Laboratory-Based Prediction of Six-Month Mortality After COVID-19 Hospitalization: Model Development, Bootstrap Internal Validation, and Single-Center Temporal Validation.Medicina (Kaunas, Lithuania) · 2026Article
- Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins.Bioscience reports · 2026Article
- Article
- Development and validation of a nomogram for predicting 30-day mortality in patients with severe acute pancreatitis and pneumonia.Scientific reports · 2025Article
- The mean corpuscular volume (MCV) is a hematological biomarker associated with COVID-19 mortality risk.Biomarkers in medicine · 2025Article
- Gaseous Ammonia Sensing from Liquids via a Portable Chemosensor with Signal Correction for Humidity.Biosensors · 2025Article
- Osmolality as a strong predictor of COVID-19 mortality and its possible links to other biomarkers.PloS one · 2025Article
- Article
- Acute kidney injury and COVID-19: the predictive power of BUN/albumin ratio for renal replacement therapy requirement.Irish journal of medical science · 2024Article
- D-dimer for efficacy prediction in COVID-19 patients treated with paxlovid.BMC infectious diseases · 2024Article
- Article
- Pulmonary fibrosis followed by severe pneumonia in patients with COVID-19 infection requiring mechanical ventilation: a prospective multicentre study.BMJ open respiratory research · 2024Article
19 more citing papers are in PubMed but not listed here.
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher (P < 0.0001). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (log-rank, P < 0.0001). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN ≥ 4.6 mmol/L and D-dimer ≥ 0.845 μg/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients.
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