Evidence map›Paper›PMID 32712273›Full record

ArticleNeuropharmacology2020

Xie2-64, a novel CB

Chloe J Jordan, Zhi-Wei Feng, Ewa Galaj, Guo-Hua Bi, Ying Xue, Ying Liang, Terence McGuire, Xiang-Qun Xie, Zheng-Xiong Xi

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chloe J JordanAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.
Zhi-Wei FengDepartment of Pharmaceutical Sciences, Computational Chemical Genomics Screen (CCGS) Center and Dept of Pharmaceutical Sciences, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research (CDAR), University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Ewa GalajAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.
Guo-Hua BiAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.
Ying XueDepartment of Pharmaceutical Sciences, Computational Chemical Genomics Screen (CCGS) Center and Dept of Pharmaceutical Sciences, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research (CDAR), University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Ying LiangAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.
Terence McGuireDepartment of Pharmaceutical Sciences, Computational Chemical Genomics Screen (CCGS) Center and Dept of Pharmaceutical Sciences, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research (CDAR), University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Xiang-Qun XieDepartment of Pharmaceutical Sciences, Computational Chemical Genomics Screen (CCGS) Center and Dept of Pharmaceutical Sciences, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research (CDAR), University of Pittsburgh, Pittsburgh, PA, 15261, USA; Drug Discovery Institute; Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address: xix15@pitt.edu.
Zheng-Xiong XiAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA. Electronic address: zxi@mail.nih.gov.
National Institute on Drug Abuse · USDiscovery Institute · US

Funding

NIDA Center of Excellence OF Computational Drug Abuse Research (CDAR)P30DA035778 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, XIE, XIANG-QUN · 2014 to 2018
$5.4M
Cannabinoid CB1 and CB2 receptors and drug abuseZIGDA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2020 to 2022
$3.6M
NOVEL DOPAMINE D3 RECEPTOR LIGANDSZ01DA000424 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 1999 to 2008
$1.8M
Intramural NIH HHS Z01 DA000424Intramural NIH HHS Z99 DA999999NIDA NIH HHS P30 DA035778
6 · The paper itself

Abstract

Cocaine abuse remains a public health threat around the world. There are no pharmacological treatments approved for cocaine use disorder. Cannabis has received growing attention as a treatment for many conditions, including addiction. Most cannabis-based medication development has focused on cannabinoid CB

Indexed as

Drug Inverse AgonismAnimalsBenzene DerivativesBenzenesulfonamidesCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCocaineCocaine-Related DisordersDopamine Uptake InhibitorsDose-Response Relationship, DrugMaleMiceMice, KnockoutProtein Structure, SecondaryRatsRats, Long-EvansBenzene DerivativesBenzenesulfonamidesCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCocaineDopamine Uptake InhibitorsReceptor, Cannabinoid, CB2SulfonamidesXie2-64CannabinoidCB(2) receptorCocaineDopamineOptogeneticsSelf-administrationXie2-64

Identifiers

PMID32712273
PMCPMC7529998
OpenAlexW3043849219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.