Evidence map›Paper›PMID 32712266›Full record

ArticleNeurobiology of disease2020

Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series.

Valerie Joers, Gunasingh Masilamoni, Doty Kempf, Alison R Weiss, Travis M Rotterman, Benjamin Murray, Gul Yalcin-Cakmakli, Ronald J Voll, Mark M Goodman, Leonard Howell and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Valerie JoersDepartment of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Physiology, Emory University, Atlanta, GA, USA. Electronic address: vjoers@ufl.edu.
Gunasingh MasilamoniYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Doty KempfYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Alison R WeissYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR, USA; Department of Psychology, Emory University, Atlanta, GA, USA.
Travis M RottermanDepartment of Physiology, Emory University, Atlanta, GA, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Benjamin MurrayDepartment of Physiology, Emory University, Atlanta, GA, USA.
Gul Yalcin-CakmakliYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Neurology, Hacettepe University, Ankara, Turkey.
Ronald J VollYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Mark M GoodmanYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Leonard HowellYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Jocelyne BachevalierYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Psychology, Emory University, Atlanta, GA, USA.
Stefan J GreenSequencing Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Ankur NaqibDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
Maliha ShaikhDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
Phillip A EngenDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
Ali KeshavarzianDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
Christopher J BarnumINmuneBio Inc., La Jolla, CA, USA.
Jonathon A NyeYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Yoland SmithYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Neurology, Emory University, Atlanta, GA, USA.
Malú G TanseyDepartment of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, USA; Department of Physiology, Emory University, Atlanta, GA, USA.
Emory University · USRush University Medical Center · USGeorgia Institute of Technology · USOregon National Primate Research Center · USUniversity of Illinois Chicago · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
NCATS NIH HHS UL1 TR000454NIEHS NIH HHS T32 ES012870NIH HHS P51 OD011132
6 · The paper itself

Abstract

Inflammation has been linked to the development of nonmotor symptoms in Parkinson's disease (PD), which greatly impact patients' quality of life and can often precede motor symptoms. Suitable animal models are critical for our understanding of the mechanisms underlying disease and the associated prodromal disturbances. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkey model is commonly seen as a "gold standard" model that closely mimics the clinical motor symptoms and the nigrostriatal dopaminergic loss of PD, however MPTP toxicity extends to other nondopaminergic regions. Yet, there are limited reports monitoring the MPTP-induced progressive central and peripheral inflammation as well as other nonmotor symptoms such as gastrointestinal function and microbiota. We report 5 cases of progressive parkinsonism in non-human primates to gain a broader understanding of MPTP-induced central and peripheral inflammatory dysfunction to understand the potential role of inflammation in prodromal/pre-motor features of PD-like degeneration. We measured inflammatory proteins in plasma and CSF and performed [

Indexed as

Disease Models, AnimalGastrointestinal MicrobiomeMacaca mulatta1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnilidesAnimalsBehavior, AnimalCognitionDisease ProgressionFatty Acids, VolatileFemaleInflammationMagnetic Resonance ImagingMaleMicrogliaNeurotoxins1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnilidesFatty Acids, VolatileN-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluorideNeurotoxinsPyridinesTumor Necrosis Factor-alphaTumor Necrosis Factor InhibitorsXENP 1595InflammationMicrobiotaMicroglia phenotypesMPTPNonmotor symptomsParkinson's diseaseRhesus monkeySex differencesTumor necrosis factorXPro1595

Identifiers

PMID32712266
PMCPMC7484290
OpenAlexW3044513361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.