Evidence map›Paper›PMID 32712222›Full record

ArticleMetabolism: clinical and experimental2020

Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19.

Mikiko Watanabe, Damiano Caruso, Dario Tuccinardi, Renata Risi, Marta Zerunian, Michela Polici, Francesco Pucciarelli, Mariarita Tarallo, Lidia Strigari, Silvia Manfrini and 5 more

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 139 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 12 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05163743 naunknown statusnot on this mapstarted 2021, after this paper: background citation

COVID-19 Vaccination in Subjects With Obesity: Impact of Metabolic Health and the Role of a Ketogenic Diet

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2021 to 2021Enrolled24ConditionsObesityArmsLow Calorie Ketogenic Diet
NCT06236932 narecruitingnot on this mapstarted 2023, after this paper: background citation

PRIN "SIDERALE": Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation

TypeinterventionalSponsorFederico II UniversityRan2023 to 2026Enrolled100ConditionsObesity, Type2diabetes, Lipodystrophy, InfectionsArmsMediterranean diet, Melatonin supplementation
3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 12 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  4. Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Mikiko WatanabeDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Damiano CarusoDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, 00189 Rome, Italy.
Dario TuccinardiDepartment of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, 00128 Rome, Italy. Electronic address: d.tuccinardi@unicampus.it.
Renata RisiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Marta ZerunianDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, 00189 Rome, Italy.
Michela PoliciDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, 00189 Rome, Italy.
Francesco PucciarelliDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, 00189 Rome, Italy.
Mariarita TaralloDepartment of Surgery "Pietro Valdoni", Sapienza University of Rome, 00161 Rome, Italy.
Lidia StrigariDepartment of Medical Physics, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Silvia ManfriniDepartment of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Stefania MarianiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Sabrina BascianiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Carla LubranoDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Andrea LaghiDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, 00189 Rome, Italy.
Lucio GnessiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Sapienza University of Rome · ITUniversità Campus Bio-Medico · ITPoliclinico S.Orsola-Malpighi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitant presence of other comorbidities. However, all reports only focus on BMI, an indirect marker of body fat.

aimTo explore the impact on COVID-19 severity of abdominal fat as a marker of body composition easily collected in patients undergoing a chest CT scan.

methodsPatients included in this retrospective study were consecutively enrolled among those admitted to an Emergency Department in Rome, Italy, who tested positive for SARS-Cov-2 and underwent a chest CT scan in March 2020. Data were extracted from electronic medical records.

results150 patients were included (64.7% male, mean age 64 ± 16 years). Visceral fat (VAT) was significantly higher in patients requiring intensive care (p = 0.032), together with age (p = 0.009), inflammation markers CRP and LDH (p < 0.0001, p = 0.003, respectively), and interstitial pneumonia severity as assessed by a Lung Severity Score (LSS) (p < 0.0001). Increasing age, lymphocytes, CRP, LDH, D-Dimer, LSS, total abdominal fat as well as VAT were found to have a significant univariate association with the need of intensive care. A multivariate analysis showed that LSS and VAT were independently associated with the need of intensive care (OR: 1.262; 95%CI: 1.0171-1.488; p = 0.005 and OR: 2.474; 95%CI: 1.017-6.019; p = 0.046, respectively).

conclusionsVAT is a marker of worse clinical outcomes in patients with COVID-19. Given the exploratory nature of our study, further investigation is needed to confirm our findings and elucidate the mechanisms underlying such association.

Indexed as

BetacoronavirusAgedAged, 80 and overBody CompositionBody Mass IndexComorbidityCoronavirus InfectionsCOVID-19C-Reactive ProteinCritical CareFemaleHumansInflammationIntra-Abdominal FatL-Lactate DehydrogenaseLungC-Reactive ProteinL-Lactate DehydrogenaseBody compositionCovid-19FatObesityRisk factorSARS-CoV-2

Identifiers

PMID32712222
PMCPMC7377788
OpenAlexW3043860046

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.