Evidence map›Paper›PMID 32712165›Full record

ArticleThe International journal on drug policy2021

Optimizing the impact of medications for opioid use disorder at release from prison and jail settings: A microsimulation modeling study.

Alexandria Macmadu, Joëlla W Adams, S E Bessey, Lauren Brinkley-Rubinstein, Rosemarie A Martin, Jennifer G Clarke, Traci C Green, Josiah D Rich, Brandon D L Marshall

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

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  6. Groundbreaking Research from NIDA Addressing the Challenges of the Opioid Epidemic.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alexandria MacmaduDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; The Center for Prisoner Health and Human Rights, The Miriam Hospital, 8 Third Street, Providence, RI 02906, USA.
Joëlla W AdamsDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA.
S E BesseyDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA.
Lauren Brinkley-RubinsteinDepartment of Social Medicine, University of North Carolina at Chapel Hill, 333 South Columbia Street, Chapel Hill, NC 27516, USA; Center for Health Equity Research, University of North Carolina at Chapel Hill, 335 South Columbia Street, Chapel Hill, NC 27514, USA.
Rosemarie A MartinDepartment of Behavioral and Social Science, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA.
Jennifer G ClarkeRhode Island Department of Corrections, 40 Howard Avenue, Cranston, RI 02920, USA.
Traci C GreenDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Department of Emergency Medicine, The Warren Alpert School of Medicine of Brown University, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA.
Josiah D RichDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; The Center for Prisoner Health and Human Rights, The Miriam Hospital, 8 Third Street, Providence, RI 02906, USA.
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA. Electronic address: brandon_marshall@brown.edu.
Brown University · USRhode Island Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI JOSIAH D RICH · 2018 to 2026
$23.4M
BU Clinical HIV/AIDS Research Training Program (BU-CHART)T32AI052074 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Benjamin P. Linas · 2003 to 2026
$6.7M
Highly Adaptive Epidemic Control Strategies for HIV Prevention in Drug UsersDP2DA040236 · NIDA · BROWN UNIVERSITY · PI MARSHALL, BRANDON DAVID LEWIS · 2015 to 2015
$2.4M
Midcareer Investigator Award in Patient Oriented ResearchK24DA022112 · NIDA · MIRIAM HOSPITAL · PI RICH, JOSIAH D · 2008 to 2017
$1.7M
Evaluating the implementation and impact of a novel medication assisted treatment program in a unified jail and prison systemR21DA044443 · NIDA · MIRIAM HOSPITAL · PI RICH, JOSIAH D · 2017 to 2018
$663k
NIAID NIH HHS T32 AI052074NIDA NIH HHS DP2 DA040236NIDA NIH HHS K24 DA022112NIDA NIH HHS R21 DA044443NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

backgroundWe examined the impact of expanded access to medications for opioid use disorder (MOUD) in a unified prison and jail system on post-release, opioid-related overdose mortality.

methodsWe developed a microsimulation model to simulate a population of 55,000 persons at risk of opioid-related overdose mortality in Rhode Island. The effect of an extended-release (XR) naltrexone only intervention and the effect of providing access to all three MOUD (i.e., methadone, buprenorphine, and XR-naltrexone) at release from incarceration on cumulative overdose death over eight years (2017-2024) were compared to the standard of care (i.e., limited access to MOUD).

resultsIn the standard of care scenario, the model predicted 2385 opioid-related overdose deaths between 2017 and 2024. An XR-naltrexone intervention averted 103 deaths (4.3% reduction), and access to all three MOUD averted 139 deaths (5.8% reduction). Among those with prior year incarceration, an XR-naltrexone only intervention and access to all three MOUD reduced overdose deaths by 22.8% and 31.6%, respectively.

conclusionsExpanded access to MOUD in prison and jail settings can reduce overdose mortality in a general, at-risk population. However, the real-world impact of this approach will vary by levels of incarceration, treatment enrollment, and post-release retention.

Indexed as

BuprenorphineOpioid-Related DisordersHumansJailsPrisonsRhode IslandBuprenorphineJailsMedications for opioid use disorderOpioidsOverdosePrisons

Identifiers

PMID32712165
PMCPMC7790977
OpenAlexW3043883645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.