ArticleThe American journal of pathology2020
Knockout of the Tachykinin Receptor 1 in the Mdr2
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Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Tachykinin Receptors and their Antagonists: Unraveling Their Role in Metabolic Disorders and Therapeutic Innovations.Current drug targets · 2025Review
- Bile acid-mediated signaling in cholestatic liver diseases.Cell & bioscience · 2023Review
- Inflammasome and pyroptosis in autoimmune liver diseases.Frontiers in immunology · 2023Review
- Gene Therapy for Acquired and Genetic Cholestasis.Biomedicines · 2022Review
- Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression.Frontiers in endocrinology · 2022Article
- Recent discoveries in microbiota dysbiosis, cholangiocytic factors, and models for studying the pathogenesis of primary sclerosing cholangitis.Open medicine (Warsaw, Poland) · 2022Review
- Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Ludovica CeciDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Heather FrancisDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
Tianhao ZhouDepartment of Medical Physiology, Texas A&M University, Bryan, Texas.
Thao GiangDepartment of Medical Physiology, Texas A&M University, Bryan, Texas.
Zhihong YangDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Fanyin MengDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
Nan WuDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Lindsey KennedyDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Konstantina KyritsiDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Vik MeadowsDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana.
Chaodong WuDepartment of Nutrition, Texas A&M University, College Station, Texas.
Suthat LiangpunsakulDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
Antonio FranchittoEleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Amelia SybengaDepartment of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, Vermont.
Burcin EkserDivision of Transplant Surgery, Department of Surgery, Indiana University, Indianapolis, Indiana.
Romina MancinelliDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Paolo OnoriDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Eugenio GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University, Bryan, Texas.
Gianfranco AlpiniDivision of Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, Indiana; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana. Electronic address: galpini@iu.edu.
Indiana University – Purdue University Indianapolis · USRichard L. Roudebush VA Medical Center · USTexas A&M University · USSapienza University of Rome · ITUniversity of Vermont Medical Center · US
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MMechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4MNeuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MRegulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MREGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435kRole of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350kBLR&D Research Career Scientist AwardIK6BX005226 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2020 to 2024
–BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX003031BLRD VA IK6 BX004601BLRD VA IK6 BX005226NIAAA NIH HHS R21 AA025157NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184NIDDK NIH HHS R01 DK119421
Abstract
Activation of the substance P (SP)/neurokinin 1 receptor (NK1R) axis triggers biliary damage/senescence and liver fibrosis in bile duct ligated and Mdr2
Indexed as
Bile DuctsCholangitis, SclerosingLiver CirrhosisAnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BDisease Models, AnimalGene Knockdown TechniquesMice, KnockoutReceptors, Neurokinin-1ATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BReceptors, Neurokinin-1
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.