Evidence map›Paper›PMID 32711710›Full record

ArticleThe lancet. Psychiatry2020

Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey.

Astrid Chevance, Philippe Ravaud, Anneka Tomlinson, Catherine Le Berre, Birgit Teufer, Suzanne Touboul, Eiko I Fried, Gerald Gartlehner, Andrea Cipriani, Viet Thi Tran

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in The lancet. Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Improvements in health-related quality of life with esketamine nasal spray versus quetiapine extended release.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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  12. Deterioration in mental health: towards a conceptualization based on patients' perspectives.International journal of qualitative studies on health and well-being · 2026
    Article
  13. Narratives of recovery from persistent fatigue: a stepwise learning process.Scandinavian journal of primary health care · 2026
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Astrid ChevanceCentre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Institute for Health and Medical Research, and French National Institute of Research for Agriculture, University of Paris, Paris, France. Electronic address: astrid.chevance@gmail.com.
Philippe RavaudCentre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Institute for Health and Medical Research, and French National Institute of Research for Agriculture, University of Paris, Paris, France; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Anneka TomlinsonDepartment of Psychiatry, University of Oxford, Oxford, UK.
Catherine Le BerreCentre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Institute for Health and Medical Research, and French National Institute of Research for Agriculture, University of Paris, Paris, France.
Birgit TeuferDepartment for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria.
Suzanne TouboulExperience Expert (patient), Paris, France.
Eiko I FriedDepartment of Clinical Psychology, Leiden University, Leiden, The Netherlands.
Gerald GartlehnerDepartment for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria; RTI International, Research Triangle Park, Durham, NC, USA.
Andrea CiprianiOxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Viet Thi TranCentre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Institute for Health and Medical Research, and French National Institute of Research for Agriculture, University of Paris, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear.

methodsWe did an international online survey in French, German, and English. Participants were adult patients with a history of depression, informal caregivers, and health-care professionals, recruited by purposeful sampling. To identify outcome domains, participants answered four open-ended questions about their expectations for depression treatment. We disseminated the survey without restriction via social media, patient and professional associations, and a media campaign. Four researchers independently did qualitative content analyses. We assessed data saturation using mathematical models to ensure the comprehensive identification of outcome domains.

findingsBetween April 5, 2018, and Dec 10, 2018, 1912 patients, 464 informal caregivers, and 627 health-care professionals from 52 countries provided 8183 open-ended answers. We identified 80 outcome domains related to symptoms (64 domains), such as mental pain (or psychological or psychic pain, 523 [17%] of 3003 participants) and motivation (384 [13%]), and functioning (16 domains), such as social isolation (541 [18%]). We identified 57 other outcome domains regarding safety of treatment, health care organisation, and social representation, such as stigmatisation (408 [14%]).

interpretationThis study provides a list of outcome domains important to patients, informal caregivers, and health-care professionals. Unfortunately, many of these domains are rarely measured in clinical trials. Results from this study should set the foundation for a core outcome set for depression.

fundingFondation pour la Recherche Medicale and NIHR Oxford Health Biomedical Research Centre.

Indexed as

AdultAustriaCaregiversDepressionEvaluation Studies as TopicFemaleFranceGermanyHealth PersonnelHumansMaleMiddle AgedMotivationNorth AmericaOutcome Assessment, Health CarePain

Identifiers

PMID32711710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.