Evidence map›Paper›PMID 32711484›Full record

ArticleBMC cancer2020

Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer.

Qiang An, Wei Liu, Yujia Yang, Bing Yang

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Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qiang AnDepartment of Gynecology, Affiliated Hospital of Zunyi Medical University, No 149, Dalian road, Zunyi City, 563100, Guizhou Province, China.
Wei LiuDepartment of Gynecology, Affiliated Hospital of Zunyi Medical University, No 149, Dalian road, Zunyi City, 563100, Guizhou Province, China.
Yujia YangDepartment of Gynecology, Affiliated Hospital of Zunyi Medical University, No 149, Dalian road, Zunyi City, 563100, Guizhou Province, China.
Bing YangDepartment of Gynecology, Affiliated Hospital of Zunyi Medical University, No 149, Dalian road, Zunyi City, 563100, Guizhou Province, China. yangbing_zy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that fibrinogen-to-albumin ratio (FAR) is a novel prognostic immune biomarker in various diseases. In this study, we investigated the role of FAR in the prognosis of patients with stage IB-IIA cervical cancer (CC).

methodsA total of 278 eligible participants with newly diagnosed CC (stage IB-IIA) who had undergone radical hysterectomy followed by adjuvant chemotherapy were enrolled in this study. Demographics, clinicopathological variables, and laboratory tests were obtained from the medical records. Risk factors for overall survival (OS) and recurrence-free survival (RFS) were evaluated by univariate and multivariate Cox proportional regression analyses. The association between OS, RFS, and FAR was assessed by the Kaplan-Meier method using log-rank test.

resultsFAR was associated with age, International Federation of Gynecology and Obstetrics (FIGO) stage, depth of the invasion, and C-reactive protein (CRP) level (P < 0.05). Preoperative FAR was an effective predictor for OS in CC patients with a cut-off value of 7.75 and an area under the curve (AUC) of 0.707 (P < 0.001). The univariate and multivariate Cox analyses indicated that FIGO stage and FAR were two independent risk factors for both OS and RFS (P < 0.05). Kaplan-Meier analysis confirmed that patients with high FAR levels showed significantly lower RFS (P = 0.004) and OS (P = 0.003) than those with low FAR levels.

conclusionsThis study indicated that elevated preoperative FAR might be a novel prognostic factor for CC patients with stage IB-IIA.

Indexed as

Age FactorsCarcinoma, Squamous CellC-Reactive ProteinDisease-Free SurvivalFemaleFibrinogenHumansHysterectomyKaplan-Meier EstimateLymph Node ExcisionMiddle AgedNeoplasm InvasivenessPrognosisProportional Hazards ModelsRegression AnalysisRetrospective StudiesC-Reactive ProteinFibrinogenSerum AlbuminBiomarkerCervical cancerFibrinogen-to-albumin ratioPrognosis

Identifiers

PMID32711484
PMCPMC7382827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.