Evidence map›Paper›PMID 32711431›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Genetic Polymorphism of Epidermal Growth Factor Gene as a Predictor of Hepatocellular Carcinoma in Hepatitis C Cirrhotic Patients.

Ibrahim Baghdadi, Khaled Abu Ella, Ahmed El Shaaraway, Elsayed Elshayeb, Hala S El-Rebey, Mohamed El Hoseeny, Mary Naguib, Ali Nada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Journal of clinical medicine · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ibrahim BaghdadiInternal Medicine Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Khaled Abu EllaLiver and Hepatobiliary surgery Department, National Liver Institute, Menoufia University, Menoufia, Egypt.
Ahmed El ShaarawayClinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.
Elsayed ElshayebInternal Medicine Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Hala S El-RebeyPathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Mohamed El HoseenyHepatology Department, Mahlla teaching liver hospital, El Mahlla, Gharbeya, Egypt.
Mary NaguibClinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.
Ali NadaHepatology Gastroenterology Department, National Liver Institute, Menofia University. Egypt.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Egypt, the incidence of hepatocellular carcinoma (HCC) is approximately 4.7% of chronic liver disease patients due to (HCV) infection. Epidermal growth factor (EGF) plays an important role in hepatocyte regeneration. A functional polymorphism in EGF 61A>G was identified; itwas associated with higher risk of HCC.

objectivesto investigate the correlation between the epidermal growth factor (EGF) polymorphism and the risk of hepatocellular carcinoma (HCC) in hepatitis C viral (HCV) cirrhotic patients as well as its relation to EGF protein expression in HCC tissue. PATIENTS AND

methodsthis casecontrol study was conducted on 75 HCV cirrhotic patients including 50 HCC patients (25 withresectable HCC and 25 with advanced unresectable HCC) and 25 healthy persons were included. EGF genotype was detected by restriction fragment length polymorphism. EGF expression in HCC tissue biopsiesfrom patientswhounderwent surgical resection was done by immunohistochemical examination.

resultsThe GG genotype was associated with significant increased risk of HCC compared to AA genotypes (P=0.031) in cirrhotic group. The G allele had a highly significant risk of HCC compared to allele Ain recessive model GG vs. AG+AA (P=0.036) rather than in the dominant model GG +AG vs. AA (P=0.66). There was significant increased expression of EGF in tumour tissues in patients with GG genotype compared to AG genotype and AA genotype p= 0.019.

conclusionEGF gene polymorphism (GG genotype) had a significant risk of HCC development in cirrhotic patients. This is confirmed by increased EGF expression in liver tumor tissue from HCC patients.<br />.

Indexed as

Polymorphism, Single NucleotideAdultAgedCarcinoma, HepatocellularCase-Control StudiesErbB ReceptorsFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHepacivirusHepatitis CHumansLiver CirrhosisLiver NeoplasmsMaleEGFR protein, humanErbB ReceptorsEpidermal growth factor gene polymorphismHepatitis C VirusHepatocellular carcinomaimmunohistochemical examinationrestriction fragment length polymorphism

Identifiers

PMID32711431
PMCPMC7573408
OpenAlexW3044102898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.