Evidence map›Paper›PMID 32711178›Full record

ArticleThe Journal of surgical research2020

Treatment and Outcomes of Early Stage Breast Cancer in Patients with Hepatic Dysfunction.

Yuliya B Olimpiadi, Kirstyn E Brownson, Jeffrey A Kahn, Brian Kim, Hyosun Han, Saro Khemichian, Tse-Ling Fong, Irene Kang, Alicia Terando, Julie E Lang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuliya B OlimpiadiDivision of Breast, Endocrine and Soft Tissue Surgery, Department of Surgery, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Kirstyn E BrownsonDivision of Breast, Endocrine and Soft Tissue Surgery, Department of Surgery, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Jeffrey A KahnLiver Transplant Program, Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California.
Brian KimLiver Transplant Program, Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California.
Hyosun HanLiver Transplant Program, Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California.
Saro KhemichianLiver Transplant Program, Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California.
Tse-Ling FongLiver Transplant Program, Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California.
Irene KangDivision of Medical Oncology, Department of Medicine, University of Southern California, Los Angeles, California.
Alicia TerandoDivision of Breast, Endocrine and Soft Tissue Surgery, Department of Surgery, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Julie E LangDivision of Breast, Endocrine and Soft Tissue Surgery, Department of Surgery, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. Electronic address: julie.Lang@med.usc.edu.
University of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

backgroundThere exists a dogma of surgical nihilism for patients with cirrhosis and breast cancer causing de-escalation of surgery and impacting survival. We hypothesized that breast cancer surgery would not result in a significant change in the Model for End-Stage Liver Disease-Sodium (MELD-Na) scores before and after surgery.

methodsWe performed a single institutional retrospective review of medical records between January 2013 and July 2019 of patients with concurrent cirrhosis and breast cancer. We used the nonparametric Friedman test to compare differences in MELD-Na scores.

resultsEight patients with both cirrhosis and breast cancer were identified. Median follow-up was 30.5 mo. Half of the patients had Child-Pugh class A cirrhosis and half had Child-Pugh class B cirrhosis. Six (75%) patients underwent lumpectomy and two (25%) underwent mastectomy. There was no statistically significant difference (P = 0.66) in median MELD-Na score before surgery (16) and after surgery (18). Two (25%) patients experienced postoperative complications. Three patients were listed for liver transplantation. Of three listed patients, two (25%) patients underwent successful liver transplantation after breast surgery. One (12.5%) patient died without transplant. Three (37.5%) patients were alive for more than 5 y after breast cancer diagnosis without evidence of cancer recurrence. The eighth patient has remained breast cancer free for more than 6 mo since her surgery.

conclusionsSurgery for patients with Child-Pugh class A and B cirrhosis and early stage breast cancer did not result in a significant change in MELD-Na score before and after surgery, suggesting that selected patients may benefit from breast cancer surgery with curative intent.

Indexed as

AgedBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansLiver CirrhosisLiver TransplantationMastectomyMiddle AgedNeoplasm Recurrence, LocalPatient SelectionPostoperative ComplicationsPrognosisRetrospective StudiesSeverity of Illness IndexBreast cancerBreast cancer surgeryCirrhosisHepatic dysfunctionLiver failureLiver transplant

Identifiers

PMID32711178
PMCPMC7854813
OpenAlexW3044748136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.