Evidence map›Paper›PMID 32710956›Full record

ArticleToxicology and applied pharmacology2020

Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice.

Sebastian Medina, Fredine T Lauer, Eliseo F Castillo, Alicia M Bolt, Abdul-Mehdi S Ali, Ke Jian Liu, Scott W Burchiel

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.Journal of exposure science & environmental epidemiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sebastian MedinaDepartment of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Fredine T LauerDepartment of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Eliseo F CastilloDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, The University of New Mexico School of Medicine, Albuquerque, NM, USA.
Alicia M BoltDepartment of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Abdul-Mehdi S AliDepartment of Department of Earth and Planetary Sciences, The University of New Mexico, Albuquerque, NM, USA.
Ke Jian LiuDepartment of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Scott W BurchielDepartment of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA. Electronic address: sburchiel@salud.unm.edu.
University of New Mexico · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research ProgramP42ES025589 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CERRATO, JOSE MANUEL · 2017 to 2025
$16.4M
The Role of Biotransformation in Arsenic-Induced HematotoxicityR01ES029369 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, KE JIAN · 2018 to 2022
$1.8M
NCI NIH HHS P30 CA118100NIEHS NIH HHS P42 ES025589NIEHS NIH HHS R01 ES029369
6 · The paper itself

Abstract

Human exposures to environmental metals, including uranium (U) and arsenic (As) are a global public health concern. Chronic exposures to U and As are linked to many adverse health effects including, immune suppression and autoimmunity. The gastrointestinal (GI) tract is home to many immune cells vital in the maintenance of systemic immune health. However, very little is known about the immunotoxicity of U and As at this site. The present study examined the burden of U and As exposure in the GI tract as well as the resultant immunotoxicity to intraepithelial lymphocytes (IELs) and innate immune cells of the small intestine following chronic drinking water exposures of male and female mice to U (in the form of uranyl acetate, UA) and As (in the form of sodium arsenite, As

Indexed as

Administration, OralAnimalsArsenicDrinking WaterFemaleImmunity, InnateIntestine, SmallMaleMiceMice, Inbred C57BLSex FactorsUraniumArsenicDrinking WaterUraniumArsenicArsenite (As(3+))Gut associated lymphoid tissuesImmunotoxicityInnate immune cellsIntraepithelial lymphocytesMetalsSmall intestineUranium

Identifiers

PMID32710956
PMCPMC7490749
OpenAlexW3044485587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.