ArticleHippocampus2020
Optogenetic "low-theta" pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.Research square · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.bioRxiv : the preprint server for biology · 2026Article
- Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways.bioRxiv : the preprint server for biology · 2026Article
- Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.bioRxiv : the preprint server for biology · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- A food-sensitive olfactory circuit drives anticipatory satiety.Nature metabolism · 2025Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Article
- Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity.Journal of neural engineering · 2024Article
- Early-life seizures alter habit behavior formation and fronto-striatal circuit dynamics.Epilepsy & behavior : E&B · 2023Article
- Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures.Hippocampus · 2023Article
- Stress degrades working memory-related frontostriatal circuit function.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Site-dependent shaping of field potential waveforms.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes.Nature communications · 2023Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration.Epilepsy & behavior : E&B · 2022Article
- Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.Frontiers in systems neuroscience · 2022Article
- Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments.Epilepsia · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal theta oscillations show prominent changes in frequency and amplitude depending on behavioral state or cognitive demands. How these dynamic changes in theta oscillations contribute to the spatial and temporal organization of hippocampal cells, and ultimately behavior, remain unclear. We used low-theta frequency optogenetic stimulation to pace coordination of cellular and network activity between the medial septum (MS) and hippocampus during baseline and MS stimulation while rats were at rest or performing a spatial accuracy task with a visible or hidden goal zone. Hippocampal receptivity to pan-neuronal septal stimulation at low-theta frequency was primarily determined by speed and secondarily by task demands. Competition between artificial and endogenous field potentials at theta frequency attenuated hippocampal phase preference relative to local theta, but the spike-timing activity of hippocampal pyramidal cells was effectively driven by artificial septal output, particularly during the hidden goal task. Notwithstanding temporal reorganization by artificial theta stimulation, place field properties were unchanged and alterations to spatial behavior were limited to goal zone approximation. Our results indicate that even a low-theta frequency timing signal in the septohippocampal circuit is sufficient for spatial goal finding behavior. The results also advance a mechanistic understanding of how endogenous or artificial somatodendritic timing signals relate to displacement computations during navigation and spatial memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.