ArticleBrain imaging and behavior2021
The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Altered Individualized Structural Covariance Networks Underlie Depressive and Anxiety Symptoms in Chronic Insomnia Disorder: A Dynamic Time Warping Graph Theory Study.Brain and behavior · 2026Article
- Altered volumetric and functional connectivity of the habenula in chronic insomnia disorder.Frontiers in neuroscience · 2026Article
- Alterations in subgenual anterior cingulate cortex functional connectivity underlie depressive symptoms in chronic insomnia disorder.Frontiers in psychiatry · 2026Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- The Pathogenesis and Treatment of Insomnia Combined with Depression.International journal of general medicine · 2025Review
- Altered functional network topology and connectivity in female nurses with shift work sleep disorder.Frontiers in systems neuroscience · 2025Article
- Article
- Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review.Neurochemical research · 2024Review
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Abnormal developmental of structural covariance networks in young adults with heavy cannabis use: a 3-year follow-up study.Translational psychiatry · 2024Article
- Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application.Frontiers in neuroscience · 2024Review
- The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.Frontiers in psychiatry · 2024Article
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Altered functional connectivity of the default mode and frontal control networks in patients with insomnia.CNS neuroscience & therapeutics · 2023Article
- The role of ascending arousal network in patients with chronic insomnia disorder.Human brain mapping · 2023Article
- The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI.Frontiers in neuroscience · 2023Article
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance.Frontiers in psychology · 2023Article
- Article
- Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study.BMC psychiatry · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Previous research has shown that acute sleep deprivation can influence the reward networks. However, it is unclear whether and how the intrinsic reward network is altered in chronic insomnia disorder (CID). In the present study, we aimed to investigate whether the reward network is altered in patients with CID using resting-state functional magnetic resonance imaging (fMRI) data. Forty-two patients with CID and 33 healthy controls (HCs) were enrolled and underwent resting-state fMRI. Nucleus accumbens (NAc) - based functional connectivity (NAFC) was evaluated to explore the differences in the reward network between the CID and HC groups. Pearson correlation analysis was used to evaluate the clinical significance of altered NAFC networks. Compared to those in the HC group, increased NAFC was found in the salience and limbic networks, while decreased NAFC was found in the default mode network (DMN) and within the reward circuit in patients with CID. In addition, decreased FC between the NAc and DMN was associated with insomnia severity, while NAFC within the reward network was associated with depression symptoms in patients with CID. These findings showed that the reward network is dysfunctional and associated with depression symptom in patients with CID. Future studies of CID should consider both insomnia and depression symptoms to disentangle the role of insomnia and depression in the relationship under study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.