SynthesisBrain imaging and behavior2021
Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.
Synthesis in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 7 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 7 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using AES-SDM.BMC psychiatry · 2026Pooled it
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.Neural plasticity · 2025Pooled it
- Abnormal changes of brain function and structure in patients with T2DM-related cognitive impairment: a neuroimaging meta-analysis and an independent validation.Nutrition & diabetes · 2024Pooled it
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- Gray and white matter abnormality in patients with T2DM-related cognitive dysfunction: a systemic review and meta-analysis.Nutrition & diabetes · 2022Pooled it
- Amygdala Reactivity, Antidepressant Discontinuation, and Relapse.JAMA psychiatry · 2024Trial
- Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study.Translational psychiatry · 2024Trial
- Mitochondrial dynamics in depression: friend or foe?Metabolic brain disease · 2026Review
- Neural Responses to Affective Sentences Reveal Signatures of Depression.Translational psychiatry · 2026Article
- Changes in brain function during negative emotion processing following cognitive-behavioural therapy in depressive disorders.The British journal of psychiatry : the journal of mental science · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Age-related regional homogeneity changes in first-episode major depressive disorder: a REST-meta-MDD project study.BMC psychiatry · 2025Article
- Normative amygdala fMRI response during emotional processing as a trait of depressive symptoms in the UK Biobank.Psychological medicine · 2025Article
- Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Insights from a methylome-wide association study of antidepressant exposure.Nature communications · 2025Article
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
- Aberrant functional connectivity and the intrinsic activity of primary visual network and their relationship with adolescent atypical depression symptoms.Frontiers in psychiatry · 2025Article
- Functional Brain Activity Alterations in Type 1 Narcolepsy Patients with Anxiety and Depression: A 7-Tesla Resting State-Functional Magnetic Resonance Imaging Study.Nature and science of sleep · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAbnormal neural activities during emotional processing have been found in both adults and youths with major depressive disorder. However, findings were inconsistent in each group and cannot be compared to each other.
methodsWe first identified neuroimaging experiments that revealed abnormal neural activities during emotional processing in patients with major depressive disorder published from January 1997 to January 2019. Then we conducted voxel-wise meta-analyses on adult and youth patients separately and compared the two age groups using direct meta-comparison.
resultsFifty-four studies comprising 1141 patients and 1242 healthy controls were identified. Both adult and youth patients showed abnormal neural activities in anterior cingulate cortex, insula, superior and middle temporal gyrus, and occipital cortex compared to healthy controls. However, hyperactivities in the superior and middle frontal gyrus, amygdala, and hippocampus were only observed in adult patients, while hyperactivity in the striatum was only found in youth patients compared to controls. In addition, compared with youths, adult patients exhibited significantly greater abnormal activities in insula, middle frontal gyrus, and hippocampus, and significantly lower abnormal activities in middle temporal gyrus, middle occipital gyrus, lingual gyrus, and striatum.
conclusionsThe common alterations confirmed the negative processing bias in major depressive disorder. Both adult and youth patients were suggested to have disturbed emotional perception, appraisal, and reactivity. However, adult patients might be more subject to the impaired appraisal and reactivity processes, while youth patients were more subject to the impaired perception process. These findings help us understand the progressive pathophysiology of major depressive disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.