ArticleSurgery today2021
Optimal extent of central lymphadenectomy for right-sided colon cancers: is lymphadenectomy beyond the superior mesenteric vein meaningful?
Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Exploration of the medial border for laparoscopic D3 lymph node dissection in right hemi-colon cancer: a systematic review and meta-analysis.Frontiers in surgery · 2025Pooled it
- Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: a systematic review.Surgical endoscopy · 2023Pooled it
- Minimally invasive surgery for right-sided colon cancer with superior mesenteric artery rotation: clinical features and short-term outcomes.Surgery today · 2026Article
- Oncologic safety of transverse colon cancer surgery without central vessel ligation of middle colic artery.Surgical endoscopy · 2024Observational
- A multicenter prospective observational study of lymph node metastasis patterns and short-term outcomes of extended lymphadenectomy in right-sided colon cancer.Annals of gastroenterological surgery · 2023Article
- Surgical and oncological outcomes of laparoscopic right hemicolectomy (D3 + CME) for colon cancer: A prospective single-center cohort study.Surgical endoscopy · 2023Article
- Clinical implications and optimal extent of lymphadenectomy for intrahepatic cholangiocarcinoma: A multicenter analysis of the therapeutic index.Annals of gastroenterological surgery · 2023Article
- Modified complete mesocolic excision with central vascular ligation by the squeezing approach in laparoscopic right colectomy.Langenbeck's archives of surgery · 2022Article
- Complete mesocolic excision (CME) and D3-lymphadenectomy (D3) for right-sided colon cancers: a potentially prognostic surgical approach.Surgery today · 2021Article
- Reply to comment on "Optimal extent of central lymphadenectomy for right-sided colon cancers: is lymphadenectomy beyond the superior mesenteric vein meaningful?"Surgery today · 2021Article
- Gastrocolic ligament lymph-node dissection may increase the incidence of delayed gastric emptying after colon cancer surgery with D3 lymphadenectomy.Surgery today · 2021Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of the current study was to assess the therapeutic benefit of lymphadenectomy according to the extent of lymphadenectomy.
methodsPatients undergoing colectomy for right-sided colon cancer were identified. Distribution of lymph node metastases (DLNM) of 1, 2 and 3 were defined as lymph node metastasis (LNM) in the pericolic nodes, the intermediate nodes and the front of the SMV near the origin of the major artery, respectively. The therapeutic index (TI) was calculated based on the frequency of LNM and the 5 year overall survival (OS) rate of patients with LNM.
resultsAmong 344 patients who met the inclusion criteria, roughly half had LNM (n = 150, 43.7%). While 107 (31.1%) and 30 (8.7%) patients had DLNM1 and DLNM2, respectively, only 13 patients (3.8%) were defined as DLNM3. However, there was no significant difference in 5 year OS by DLNM (DLNM1 71.1%, DLNM2 78.7%, DLNM3 50.4%, p = 0.61). Overall, the TI of lymphadenectomy for D3 area was approximately 1/10 of the TI for D1 (1.9 vs.22.1), given the low frequency of LNM (3.8%) and poor 5 year OS of patients with LNM (50.4%). This trend was consistent irrespective of primary tumor locations.
conclusionThe survival benefit from central lymphadenectomy namely D3 was low among patients with right-sided colon cancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.